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Table 1 Irritation scores (IS), their standard deviation (STD) and irritation thresholds (IT) of antiseptics

From: Evaluation of the tissue toxicity of antiseptics by the hen's egg test on the chorioallantoic membrane (HETCAM)

Product‰

Substance

IS MV (STD)

IS Lit. 15, 16

IT

negative controls

     

Rinsing solutions

0,9% physiological saline, Ringer solution

0.0

(0.0)

  

Buffered solution

Phosphate-buffered saline

0.0

(0.0)

  

positive controls

     

1% SDS

Sodium dodecyl sulfat

16.9

(1.5)

  

solutions

     

Dettol™ 1 : 14

0.35% chloroxylenol + 0.8% denaturated alcohol

17.4

(0.0)

 

1 : 500

cutasept™

72% isopropanol

18.2

(0.8)

18.0

1 : 200

Octenisept™

0.1% octenidin-2HCl

14.8

(5.1)

14.0

1 : 100

Betaisodona™

10% PVP-I

5.3

(1.6)

 

1 : 10

Betaisodona™ 1:10

1% PVP-I

1.3

(0.8)

2.0

 

Prontosan™

0.1% polyhexanid

1.6

(2.7)

  

Lavanid™

0.04% polyhexanid

0.0

(0.0)

0.0

 

MDT

sterile washings from Lucilia sericata maggots

0.0

(0.0)

  

Ointments, pellets

     

Iruxol-n™

Enzyme filtrations from Clostridium histolyticum

0.0

(0.0)

  

Flammazine™

1% silver-sulfadiazine

1.3

(2.2)

  

Betaisodona™

10% PVP-I

15.8

(2.1)

  

Repithel™

3% lysosomal PVP-I

4.8

(2.1)

  

Iodosorb™ ointment

1,8% cadexomer-iodine

8.3

(3.5)

  

Iodosorb™ pellets

1% cadexomer-iodine

5.7

(3.5)

  
  1. IS Lit. = irritation scores of former studies.