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Table 1 Irritation scores (IS), their standard deviation (STD) and irritation thresholds (IT) of antiseptics

From: Evaluation of the tissue toxicity of antiseptics by the hen's egg test on the chorioallantoic membrane (HETCAM)

Product‰ Substance IS MV (STD) IS Lit. 15, 16 IT
negative controls      
Rinsing solutions 0,9% physiological saline, Ringer solution 0.0 (0.0)   
Buffered solution Phosphate-buffered saline 0.0 (0.0)   
positive controls      
1% SDS Sodium dodecyl sulfat 16.9 (1.5)   
solutions      
Dettol™ 1 : 14 0.35% chloroxylenol + 0.8% denaturated alcohol 17.4 (0.0)   1 : 500
cutasept™ 72% isopropanol 18.2 (0.8) 18.0 1 : 200
Octenisept™ 0.1% octenidin-2HCl 14.8 (5.1) 14.0 1 : 100
Betaisodona™ 10% PVP-I 5.3 (1.6)   1 : 10
Betaisodona™ 1:10 1% PVP-I 1.3 (0.8) 2.0  
Prontosan™ 0.1% polyhexanid 1.6 (2.7)   
Lavanid™ 0.04% polyhexanid 0.0 (0.0) 0.0  
MDT sterile washings from Lucilia sericata maggots 0.0 (0.0)   
Ointments, pellets      
Iruxol-n™ Enzyme filtrations from Clostridium histolyticum 0.0 (0.0)   
Flammazine™ 1% silver-sulfadiazine 1.3 (2.2)   
Betaisodona™ 10% PVP-I 15.8 (2.1)   
Repithel™ 3% lysosomal PVP-I 4.8 (2.1)   
Iodosorb™ ointment 1,8% cadexomer-iodine 8.3 (3.5)   
Iodosorb™ pellets 1% cadexomer-iodine 5.7 (3.5)   
  1. IS Lit. = irritation scores of former studies.