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Table 2 Angioirritative potential of antiseptics in long term application

From: Evaluation of the tissue toxicity of antiseptics by the hen's egg test on the chorioallantoic membrane (HETCAM)

Product™ Substance Reaction Time [min]
negative controls    
Rinsing solutions 0,9% physiological saline, Ringer solution no 60
Buffered solution PBS no 60
positive control    
1% SDS Sodium dodecyl sulfat severe 5
solutions:    
Dettol™ 0.35% chloroxylenol + 0.8% denaturated alcohol severe 5
Cutasept™ 72% isopropanol severe 5
Octenisept™ 0.1% octenidin - 2HCL severe 5
Betaisodona™ 10% PVP-I severe 60
Betaisodona™ 1:10 1% PVP-I severe 60
Prontosan™ 0.1% polyhexanid severe 60
Lavanid™ 0.04% polyhexanid no 60
MDT sterile washings from Lucilia sericata maggots no 60
Ointments, pellets    
Iruxol-n™ Enzyme filtrations from Clostridium histolyticum no 5
Flammazine™ 1% silver-sulfadiazine slight 5
Betaisodona™ ointment 10% PVP-I severe 5
Repithel™ 3% lysosomal PVP-I moderate 60
Iodosorb™ 1,8% cadexomer-iodine moderate 60
Iodosorb™ Pellets 1% cadexomer-iodine moderate 60