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Table 2 Angioirritative potential of antiseptics in long term application

From: Evaluation of the tissue toxicity of antiseptics by the hen's egg test on the chorioallantoic membrane (HETCAM)

Product™

Substance

Reaction

Time [min]

negative controls

   

Rinsing solutions

0,9% physiological saline, Ringer solution

no

60

Buffered solution

PBS

no

60

positive control

   

1% SDS

Sodium dodecyl sulfat

severe

5

solutions:

   

Dettol™

0.35% chloroxylenol + 0.8% denaturated alcohol

severe

5

Cutasept™

72% isopropanol

severe

5

Octenisept™

0.1% octenidin - 2HCL

severe

5

Betaisodona™

10% PVP-I

severe

60

Betaisodona™ 1:10

1% PVP-I

severe

60

Prontosan™

0.1% polyhexanid

severe

60

Lavanid™

0.04% polyhexanid

no

60

MDT

sterile washings from Lucilia sericata maggots

no

60

Ointments, pellets

   

Iruxol-n™

Enzyme filtrations from Clostridium histolyticum

no

5

Flammazine™

1% silver-sulfadiazine

slight

5

Betaisodona™ ointment

10% PVP-I

severe

5

Repithel™

3% lysosomal PVP-I

moderate

60

Iodosorb™

1,8% cadexomer-iodine

moderate

60

Iodosorb™ Pellets

1% cadexomer-iodine

moderate

60