Table 2 ADP-induced platelet aggregation in four subjects treated with clopidogrel with and without PPI co-therapy

#1 (wt/wt)

#2 (wt/wt)

#3 (wt/*2)

#4 (wt/*2)

baseline

normal

normal

normal

normal

(day 0)

85 U

79 U

89 U

101 U

clopidogrel mono-therapy

inhibited

inhibited

normal

inhibited

(day 7)

42 U

16 U

97 U

31 U

clopidogrel and omeprazole

inhibited

inhibited

n.s.*

normal

taken together (day 14)

44 U

10 U

74 U

clopidogrel and omeprazole

n.s.*

n.s.*

n.s*

normal

intake separated (day 21)

67 U

clopidogrel and rabeprazole

n.s.*

n.s.*

n.s.*

inhibited

taken together (day 28)

43 U