From: In vitro chemosensitivity of head and neck cancer cell lines
Cell line | Cisplatin | Carboplatin | 5-FU | MTX | Bleomycin | Vincristine |
---|---|---|---|---|---|---|
UM-SCC 10A | 3.4 (3.1-3.71) | 37 (32-44) | 4,677 (2,238-9,772) | 2,000 | 234 (214-257) | 0.009 (0.007-0.011) |
UM-SCC 10B | 2.6 (2G.5-2.8) | 25 (23-27) | 490 (331-724) | 2,000 | 21 (20-23) | 0.01 (0.009-0.013) |
UM-SCC 11B | 0.76 (0.72-0.79) | 11 (10-12) | 2.3 (1.9-2.8) | 0.04 | 4.4 (4.2-4.6) | 0.002 (0.002-0.002) |
UM-SCC 14A | 0.44 (0.38-0.49) | 7.6 (7.1-8.1) | 7.9 (6.9-9.1) | 0.06 | 38 (31-47) | 55 |
UM-SCC 14B | 0.52 (0.48-0.57) | 17 (16-18) | 6.5 (4.9-8.5) | 0.07 | 24 (20-29) | 47 |
UM-SCC 14C | 0.78 (0.76-0.79) | 13 (12-14) | 6.3 (5.8-6.9) | 6 | 30 (28-32) | 80 |
UM-SCC 22 B | 1.1 (1.0-1.2) | 12 (11-13) | 4.5 (4.0-5.0) | 2,000 | 13 (11-15) | 0.009 (0.008-0.009) |
Hlac 79 | 0.9 (0.8-1.0) | 24 (22-26) | 48 (41-56) | 230 | 3.4 (2.2-5.2) | 0.003 (0.002-0.003) |
8029 NA | 1.2 (1.1-1.3) | 23 (22-25) | 105 (98-112) | 330 | 9.5 (7.8-12) | 0.003 (0.003-0.004) |
8029 DDP cisplatin resistant | 5.8 (5.6-5.9) | 105 (102-107) | 69 (63-76) | 1,800 | 288 (275-302) | 0.008 (0.007-0.009) |
IC50-Range [μg/ml] | 0.44-5.8 | 7.6-105 | 2.3-4,677 | 0.04-2,000 | 3.4-288 | 0.002-80 |
Variation [×-times] | 13 | 14 | 2,030 | 50,000 | 85 | 40,000 |
Standard dose i.v. in Patient | 100 mg/m2 | 400 mg/m2 | 15 mg/kg | 30 mg/m2 | 15 U/m2 | 0.025 mg/kg |
Max. Plasma Cone. [μg/ml] | 1.7-2.5 | 20-35 | 60-200 | 2-4 | 10 - 40 | 0.37 - 1 |
IC50 values | lower | in range | higher | than MPC values |