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Table 2 Drug concentrations which lead to a 50% inhibition of cell growth (IC50) were determined for each cell line using six common antineoplastic agents.

From: In vitro chemosensitivity of head and neck cancer cell lines

Cell line Cisplatin Carboplatin 5-FU MTX Bleomycin Vincristine
UM-SCC 10A 3.4 (3.1-3.71) 37
(32-44)
4,677
(2,238-9,772)
2,000 234
(214-257)
0.009
(0.007-0.011)
UM-SCC 10B 2.6
(2G.5-2.8)
25
(23-27)
490
(331-724)
2,000 21
(20-23)
0.01
(0.009-0.013)
UM-SCC 11B 0.76
(0.72-0.79)
11
(10-12)
2.3 (1.9-2.8) 0.04 4.4
(4.2-4.6)
0.002
(0.002-0.002)
UM-SCC 14A 0.44
(0.38-0.49)
7.6 (7.1-8.1) 7.9 (6.9-9.1) 0.06 38
(31-47)
55
UM-SCC 14B 0.52
(0.48-0.57)
17
(16-18)
6.5 (4.9-8.5) 0.07 24
(20-29)
47
UM-SCC 14C 0.78
(0.76-0.79)
13
(12-14)
6.3 (5.8-6.9) 6 30
(28-32)
80
UM-SCC 22 B 1.1 (1.0-1.2) 12
(11-13)
4.5 (4.0-5.0) 2,000 13
(11-15)
0.009
(0.008-0.009)
Hlac 79 0.9 (0.8-1.0) 24
(22-26)
48
(41-56)
230 3.4
(2.2-5.2)
0.003
(0.002-0.003)
8029 NA 1.2 (1.1-1.3) 23
(22-25)
105
(98-112)
330 9.5
(7.8-12)
0.003
(0.003-0.004)
8029 DDP cisplatin resistant 5.8
(5.6-5.9)
105
(102-107)
69
(63-76)
1,800 288
(275-302)
0.008
(0.007-0.009)
IC50-Range
[μg/ml]
0.44-5.8 7.6-105 2.3-4,677 0.04-2,000 3.4-288 0.002-80
Variation
[×-times]
13 14 2,030 50,000 85 40,000
Standard dose i.v. in Patient 100 mg/m2 400 mg/m2 15 mg/kg 30 mg/m2 15 U/m2 0.025 mg/kg
Max. Plasma Cone. [μg/ml] 1.7-2.5 20-35 60-200 2-4 10 - 40 0.37 - 1
IC50 values lower in range higher than MPC values
  1. Standard errors (SE) on a logarithmic scale are given in parentheses. Data for MTX, and partly for VCR, were determined in the corresponding graph due to their non-sigmoid curves. No SE were calculated for MTX and partly for VCR because of the linear response curves. The range of IC50 values is displayed for each cytostatic drug. The quotient of the highest and lowest IC50 value is displayed in the variation row. Maximum plasma concentrations (MPC) are based on in vivo measurements performed as described.