From: Central antitussive effect of codeine in the anesthetized rabbit
IV | 9 rabbits - 7 males + 2 females (3.71 ± 0.15 kg) | ||||
---|---|---|---|---|---|
dose | CN | % dif DIA | % dif ABD | % dif EP I | %dif EP E |
saline | 2.6 ± 0.7 | 100 | 100 | 100 | 100 |
0.2 | 1.9 ± 0.5 | 80 ± 9 | 73 ± 15 | 94 ± 8 | 66 ± 13 |
0.8 | 1.9 ± 0.5 | 97 ± 13 | 83 ± 12 | 90 ± 13 | 81 ± 17 |
4 | 1.2 ± 0.4** | 63 ± 14 | 51 ± 12*+ | 68 ± 12 | 52 ± 13++ |
ANOVA | P < 0.05 | P > 0.05 | P < 0.05 | P > 0.05 | P > 0.05 |
ICV | 9 rabbits - 5 males + 4 females (3.94 ± 0.15 kg) | ||||
dose | CN | % dif DIA | % dif ABD | % dif EP I | %dif EP E |
aCSF | 2.3 ± 0.6 | 100 | 100 | 100 | 100 |
0.02 | 1.5 ± 0.3 | 84 ± 18 | 102 ± 27 | 97 ± 21 | 91 ± 17 |
0.08 | 1.0 ± 0.2*++ | 79 ± 14 | 85 ± 19 | 102 ± 16 | 86 ± 19 |
0.4 | 0.8 ± 0.2**++ | 64 ± 17 | 50 ± 19*+#& | 101 ± 26 | 50 ± 16* |
recovery | 2.5 ± 0.4 | 87 ± 8 | 117 ± 10 | 134 ± 18 | 89 ± 10 |
ANOVA | P = 0.001 | P > 0.05 | P < 0.05 | P > 0.05 | P < 0.05 |