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Table 3 Steps of the off-label-use if therapeutic alternatives are missing.

From: Off-label use in germany - a current appraisal of gynaecologic university departments

Step Severity of disease Off-label use
1 No severe disease No off-label use
2 Severe disease Off label use in well founded chance of success
3 Life-threatening disease Off-label use as well as in lower chance of success
  1. (out of reference [11])