Constitutive activation and accelerated maturation of peripheral blood t cells in healthy adults in burkina faso compared to Germany: The case of malaria?

Table 2 Comparison of clinical and immunological parameters between healthy adults in Burkina Faso and Germany

	Germany	Burkina Faso	p
n =	20	40
Female [n = ]	13 (65%)	18 (45%)	-
Age [median, range]	28 (23-38)	27 (19-37)	0.68
Naive CD4 ⁺ lymphocytes
CD45^bright CCR7⁺ [% of CD4⁺ lymphocytes]	38 (16-60)	22 (3-48)	< 0.0001
CD4 ⁺ T-cell activation
CD95⁺ [% of CD4⁺ T-cells J	72 (57-100)	84 (50-97)	0.002
CD95-ABC of CD4⁺CD95^dimT-cells [AUJ	108 (65-619)	26.3 (196-686)	< 0.0001
CD95-ABC of CD4⁺CD95^brightT-cells [AUJ	2996 (1655-5331)	3316 (1474-5285)	0.05
Naïve CD8 ⁺ lymphocytes
CD45^bright CCR7⁺ [% of CD8⁺ lymphocytes]	26 (6-53)	23 (5-52)	0.56
CD8 ⁺ T-cell activation
CD38+ [% of CD8⁺ T-cells]	67 (56-97)	77 (35-99)	0.03
CD38-ABC of CD8⁺CD38⁺T-cells [AU]	1384 (440-3270)	1560 (866-2450)	0.33

If not otherwise indicated, median values with 10^th and 90^th percentiles in parentheses are shown. The Mann-Whitney U-test was used to compare groups. Abbreviations: ABC = Antibody binding capacity, AU = arbitrary units.

ISSN: 2047-783X