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Table 1 Pharmacokinetic properties of voriconazole and posaconazole.

From: Pharmacology and metabolism of voriconazole and posaconazole in the treatment of invasive aspergillosis-review of the literature

Property Posaconazole Voriconazole
Bioavailability variable
(depending on dosage regimen and food)
> 95%
Protein binding > 98% 58%
Vd/F (L/kg) 7-25 4.6
Tmax (h) 3-6 1-2
Metabolism hepatic: glucuronidation hepatic: CYP2C19, 2C9, 3 A4
T1/2 (h) 15-35 6-24
Elimination route < 1% excreted unchanged in urine 66% excreted unchanged in faeces hepatic; < 2% excreted unchanged in urine
  1. T1/2: elimination half life; tmax: time to reach the maximum plasma concentration; Vd/F: apparent volume of distribution after oral administration