Table 1 Pharmacokinetic properties of voriconazole and posaconazole.

Bioavailability

variable

(depending on dosage regimen and food)

> 95%

Protein binding

> 98%

58%

Vd/F (L/kg)

7-25

4.6

T_max (h)

3-6

1-2

Metabolism

hepatic: glucuronidation

hepatic: CYP2C19, 2C9, 3 A4

T_1/2 (h)

15-35

6-24

Elimination route

< 1% excreted unchanged in urine 66% excreted unchanged in faeces

hepatic; < 2% excreted unchanged in urine