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Table 3 Pharmacodynamic parameters of voriconazole.

From: Pharmacology and metabolism of voriconazole and posaconazole in the treatment of invasive aspergillosis-review of the literature

Parameter Characteristics
Activity Candida: fungistatic
Aspergillus: fungicidal
Time course of activity Candida: time-dependent fungistatic
Aspergillus: time-dependent slowly
fungicidal
PAFE in vitro Candida: no PAFE
Aspergillus: short PAFE
  1. PAFE, post-antifungal effect