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Table 4 Drug interactions with Posaconazole.

From: Pharmacology and metabolism of voriconazole and posaconazole in the treatment of invasive aspergillosis-review of the literature

Drug Management
Concentration increased by posaconazole  
Atazanavir Monitoring
Cyclosporine reduce dose
Lorazepam contraindicated
Midazolam reduce dose
Sirolimus contraindicated
Tacrolimus reduce dose
Concentration is increased by posaconazole/decreases posaconazole concentration
Phenytoin avoid co-administration
Rifabutin avoid co-administration
Decreases posaconazole concentration
Cimetidine avoid co-administration
Efavirenz avoid co-administration
Concentration may be increased by posaconazole  
Alprazolam reduce dose
Amiodarone monitoring
Astemizole contraindicated
Benzodiazepines monitoring
Calcium channel blockers monitoring
Carbamazepine monitoring
Cisapride contraindicated
Corticosteroid monitoring
Digoxin monitoring
Drugs for erectile dysfunction (e.g. sildenafil) monitoring
Ergot alkaloids contraindicated
HMG-CoA reductase inhibitors monitoring
Irinotecan monitoring
Quinidine contraindicated
Sulfonylureas monitoring
Terfenadine reduce dose
Vinca alkaloids monitoring
May decrease posaconazole concentrations
Famotidine avoid co-administration
Omeprazole avoid co-administration
Ranitidine avoid co-administration
Rifampin monitoring