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Table 4 Drug interactions with Posaconazole.

From: Pharmacology and metabolism of voriconazole and posaconazole in the treatment of invasive aspergillosis-review of the literature

Drug

Management

Concentration increased by posaconazole

 

Atazanavir

Monitoring

Cyclosporine

reduce dose

Lorazepam

contraindicated

Midazolam

reduce dose

Sirolimus

contraindicated

Tacrolimus

reduce dose

Concentration is increased by posaconazole/decreases posaconazole concentration

Phenytoin

avoid co-administration

Rifabutin

avoid co-administration

Decreases posaconazole concentration

Cimetidine

avoid co-administration

Efavirenz

avoid co-administration

Concentration may be increased by posaconazole

 

Alprazolam

reduce dose

Amiodarone

monitoring

Astemizole

contraindicated

Benzodiazepines

monitoring

Calcium channel blockers

monitoring

Carbamazepine

monitoring

Cisapride

contraindicated

Corticosteroid

monitoring

Digoxin

monitoring

Drugs for erectile dysfunction (e.g. sildenafil)

monitoring

Ergot alkaloids

contraindicated

HMG-CoA reductase inhibitors

monitoring

Irinotecan

monitoring

Quinidine

contraindicated

Sulfonylureas

monitoring

Terfenadine

reduce dose

Vinca alkaloids

monitoring

May decrease posaconazole concentrations

Famotidine

avoid co-administration

Omeprazole

avoid co-administration

Ranitidine

avoid co-administration

Rifampin

monitoring