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Table 2 Clinical overview of azole resistance in A. fumigatus

From: Epidemiology and antifungal resistance in invasive aspergillosis according to primary disease - review of the literature

Location

Clinical presentation

Epidemiology

Pathomechanism

Nijmegen

Invasive pulmonary aspergillosis

Mainly azole naive

Dominant resistance

 

CNS aspergillosis

Previous azole

mechanism:

 

Osteomyelitis

exposure

TR/l98H

Manchester

Chronic aspergillosis

Previous azole

Multiple resistance

 

Aspergilloma

exposure

mechanisms:

 

ABPA

 

G448S, M220, P216L,

 

CNS aspergillosis

 

TR/l98H

  1. ABPA = allergic bronchopulmonary aspergillosis