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Table 2 Clinical overview of azole resistance in A. fumigatus

From: Epidemiology and antifungal resistance in invasive aspergillosis according to primary disease - review of the literature

Location Clinical presentation Epidemiology Pathomechanism
Nijmegen Invasive pulmonary aspergillosis Mainly azole naive Dominant resistance
  CNS aspergillosis Previous azole mechanism:
  Osteomyelitis exposure TR/l98H
Manchester Chronic aspergillosis Previous azole Multiple resistance
  Aspergilloma exposure mechanisms:
  ABPA   G448S, M220, P216L,
  CNS aspergillosis   TR/l98H
  1. ABPA = allergic bronchopulmonary aspergillosis