Location | Clinical presentation | Epidemiology | Pathomechanism |
---|---|---|---|
Nijmegen | Invasive pulmonary aspergillosis | Mainly azole naive | Dominant resistance |
 | CNS aspergillosis | Previous azole | mechanism: |
 | Osteomyelitis | exposure | TR/l98H |
Manchester | Chronic aspergillosis | Previous azole | Multiple resistance |
 | Aspergilloma | exposure | mechanisms: |
 | ABPA |  | G448S, M220, P216L, |
 | CNS aspergillosis |  | TR/l98H |