Place of echinocandins in the primary treatment of invasive candidiasis in adult non-neutropenic patients. Modified algorithm based on current guidelines . * Hemodynamic instability and/or single/multiple organ failure, i.e. most patients on intensive care units. ** Clinical improvement, resolution of clinical and paraclinical signs of inflammation, initial isolate susceptible to fluconazole or voriconazole, adequate gastrointestinal function for absorption.