Table 4 In vitro susceptibilities of Candida spp. to fluconazole and voriconazole as determined by CLSI disk diffusion testing^a [9].

From: Epidemiology and antifungal resistance in invasive candidiasis

		Fluconazole^b			Voriconazole^b
Species	No. of isolates	% S	% R	No. of isolates	% S	% R
C. albicans	128,625	98.0	1.4	125,965	98,5	1.2
C. glabrata	23,305	68.7	15.7	22,968	82.9	10.0
C. tropicalis	15,546	91.0	4.1	15,198	89.5	5.4
C. parapsilosis	12,788	93.2	3.6	12,453	97.0	1.8
C. krusei	5,079	8.6	78.3	5,005	83.2	7.6
C. guilliermondii	1,410	73.5	11.4	1,375	90.5	5.7
C. lusitaniae	1,233	92.1	5.4	1,215	96.7	2.0
C. kefyr	1,044	96.5	2.7	1,032	98.7	0.9
C. inconspicua	566	22.6	53.2	563	90.6	3.9
C. famata	622	79.1	10.3	606	90.3	5.0
C. rugosa	603	49.9	41.8	580	69.3	21.2
C. dubliniensis	310	96.1	2.6	308	98.4	1.0
C. norvegensis	248	41.9	40.7	247	91.5	4.0
C. lipolytica	130	66.2	28.5	128	77.3	14.1
C. sake	87	85.1	11.5	87	92.0	6.9
C. pelliculosa	87	89.7	6.9	86	94.2	4.7
C. apicola	57	98.2	1.8	57	98.2	1.8
C. zeylanoides	70	67.1	24.3	67	85.1	6.0
C. valida	21	23.8	61.9	22	81.8	13.6
C. intermedia	24	95.8	4.2	25	100.0	0.0
C. pulcherrima	14	100.0	0.0	14	100.0	0.0
C. haemulonii	9	88.9	11.1	9	88.9	11.1
C. stellatoidea	7	85.7	0.0	7	85.7	14.3
C. utilis	6	83.3	0.0	7	100.0	0.0
C. humicola	6	50.0	50.0	6	50.0	33.3
C. lambica	5	0.0	80.0	5	40.0	20
C. ciferrii	2	50.0	50.0	2	50.0	0.0
C. colliculosa	2	100.0	0.0	2	100.0	0.0
C. holmii	1	100.0	0.0	1	100.0	0.0
C. marina	1	0.0	0.0	1	100.0	0.0
C. sphaerica	1	100.0	0.0	1	100.0	0.0
Candida spp.	9,744	86.2	8.9	9,577	93.6	4.1

^a Isolates were obtained from 133 istitutions, 2001 tp 2007.
^b Fluconazole and voriconazole disk diffusion testing was performed in accordance with CLSI document M44-a (7). the interpretive breakpoint (zone diameters) were as follows: s, ≥19 mm (fluconazole) and ≥ 17 min (voriconazole); R, ≤14 mm (fluconazole) and = 13 mm (voriconazole).
^c Candida species, not otherwise specified.

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