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Table 4 In vitro susceptibilities of Candida spp. to fluconazole and voriconazole as determined by CLSI disk diffusion testinga [9].

From: Epidemiology and antifungal resistance in invasive candidiasis

   Fluconazoleb    Voriconazoleb  
Species No. of isolates % S % R No. of isolates % S % R
C. albicans 128,625 98.0 1.4 125,965 98,5 1.2
C. glabrata 23,305 68.7 15.7 22,968 82.9 10.0
C. tropicalis 15,546 91.0 4.1 15,198 89.5 5.4
C. parapsilosis 12,788 93.2 3.6 12,453 97.0 1.8
C. krusei 5,079 8.6 78.3 5,005 83.2 7.6
C. guilliermondii 1,410 73.5 11.4 1,375 90.5 5.7
C. lusitaniae 1,233 92.1 5.4 1,215 96.7 2.0
C. kefyr 1,044 96.5 2.7 1,032 98.7 0.9
C. inconspicua 566 22.6 53.2 563 90.6 3.9
C. famata 622 79.1 10.3 606 90.3 5.0
C. rugosa 603 49.9 41.8 580 69.3 21.2
C. dubliniensis 310 96.1 2.6 308 98.4 1.0
C. norvegensis 248 41.9 40.7 247 91.5 4.0
C. lipolytica 130 66.2 28.5 128 77.3 14.1
C. sake 87 85.1 11.5 87 92.0 6.9
C. pelliculosa 87 89.7 6.9 86 94.2 4.7
C. apicola 57 98.2 1.8 57 98.2 1.8
C. zeylanoides 70 67.1 24.3 67 85.1 6.0
C. valida 21 23.8 61.9 22 81.8 13.6
C. intermedia 24 95.8 4.2 25 100.0 0.0
C. pulcherrima 14 100.0 0.0 14 100.0 0.0
C. haemulonii 9 88.9 11.1 9 88.9 11.1
C. stellatoidea 7 85.7 0.0 7 85.7 14.3
C. utilis 6 83.3 0.0 7 100.0 0.0
C. humicola 6 50.0 50.0 6 50.0 33.3
C. lambica 5 0.0 80.0 5 40.0 20
C. ciferrii 2 50.0 50.0 2 50.0 0.0
C. colliculosa 2 100.0 0.0 2 100.0 0.0
C. holmii 1 100.0 0.0 1 100.0 0.0
C. marina 1 0.0 0.0 1 100.0 0.0
C. sphaerica 1 100.0 0.0 1 100.0 0.0
Candida spp. 9,744 86.2 8.9 9,577 93.6 4.1
  1. a Isolates were obtained from 133 istitutions, 2001 tp 2007.
  2. b Fluconazole and voriconazole disk diffusion testing was performed in accordance with CLSI document M44-a (7). the interpretive breakpoint (zone diameters) were as follows: s, ≥19 mm (fluconazole) and ≥ 17 min (voriconazole); R, ≤14 mm (fluconazole) and = 13 mm (voriconazole).
  3. c Candida species, not otherwise specified.