Table 5 In vitro susceptibilities of 5,346 clinical isolates of Candida spp. to anidulafungin, caspofingin, and micafungin [38].
From: Epidemiology and antifungal resistance in invasive candidiasis
Organism | No. of isloates tested | Antifungal agent |  | Cumulative % of isolates susceptible at a MIc (μg/ml) ofa |  |  | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|  |  |  | 0.007 | 0.015 | 0.03 | 0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | ≥8 |
C. albicans | 2,869 | Anidulafungin | 6.2 | 33.5 | 69.5 | 92.4 | 99.1 | 99.5 | 99.5 | 99.6 | 100.0 | Â | Â |
| Â | Â | Caspofungin | 1.7 | 26.7 | 74.2 | 97.1 | 99.3 | 99.9 | 100.0 | Â | Â | Â | Â |
| Â | Â | Micafungin | 11.9 | 80.6 | 96.4 | 99.3 | 99.4 | 99.5 | 99.6 | 100.0 | Â | Â | Â |
C. parapsilosis | 759 | Anidulafungin | Â | Â | 0.3 | 0.3 | 0.3 | 1.4 | 4.7 | 27.9 | 92.5 | 100.0 | Â |
| Â | Â | Caspofungin | Â | 0.1 | 0.5 | 3.3 | 10.7 | 52.2 | 89.5 | 98.6 | 99.9 | 100.0 | Â |
| Â | Â | Micafungin | Â | 0.1 | 0.3 | 0.3 | 0.5 | 6.1 | 24.4 | 79.3 | 100.0 | Â | Â |
C. glabrata | 747 | Anidulafungin | Â | 0.4 | 7.8 | 62.4 | 93.6 | 99.4 | 99.7 | 99.9 | 99.9 | 100.0 | Â |
| Â | Â | Caspofungin | Â | 7.0 | 65.2 | 95.3 | 98.4 | 99.2 | 99.7 | 99.9 | 99.9 | 99.9 | 100.0 |
| Â | Â | Micafungin | 13.7 | 91.4 | 97.9 | 98.9 | 99.5 | 99.9 | 99.9 | 100.0 | Â | Â | Â |
C. tropicalis | 625 | Anidulafungin | 3.2 | 24.2 | 75.7 | 95.0 | 98.4 | 99.4 | 99.5 | 99.5 | 100.0 | Â | Â |
| Â | Â | Caspofungin | 1.3 | 31.0 | 79.7 | 97.3 | 99.0 | 99.7 | 99.7 | 99.8 | 99.8 | 99.8 | 100.0 |
| Â | Â | Micafungin | 4.0 | 39.5 | 77.6 | 96.3 | 98.6 | 99.5 | 99.7 | 100.0 | Â | Â | Â |
C. krusei | 136 | Anidulafungin | Â | 2.9 | 47.1 | 90.4 | 99.3 | 99.3 | 100.0 | Â | Â | Â | Â |
| Â | Â | Caspofungin | Â | 0.7 | 0.7 | 41.9 | 75.7 | 94.9 | 99.3 | 100.0 | Â | Â | Â |
| Â | Â | Micafungin | Â | 2.2 | 13.2 | 85.3 | 96.3 | 100.0 | Â | Â | Â | Â | Â |
C. guilliermondii | 61 | Anidulafungin | Â | Â | Â | Â | 3.3 | 6.6 | 13.1 | 57.4 | 90.2 | 100.0 | Â |
| Â | Â | Caspofungin | Â | Â | 1.6 | 4.9 | 11.5 | 39.3 | 80.3 | 95.1 | 95.1 | 95.1 | 100.0 |
| Â | Â | Micafungin | Â | 3.3 | 3.3 | 6.6 | 11.5 | 21.3 | 65.6 | 98.4 | 100.0 | Â | Â |
C. lusitaniae | 58 | Anidulafungin | Â | Â | Â | 1.7 | 13.8 | 43.1 | 96.6 | 100.0 | Â | Â | Â |
| Â | Â | Caspofungin | Â | Â | 3.4 | 6.9 | 44.8 | 89.7 | 96.6 | 100.0 | Â | Â | Â |
| Â | Â | Micafungin | Â | Â | 1.7 | 8.6 | 63.8 | 96.6 | 98.3 | 100.0 | Â | Â | Â |
C. kefyr | 37 | Anidulafungin | Â | 2.7 | 10.8 | 56.8 | 100.0 | Â | Â | Â | Â | Â | Â |
| Â | Â | Caspofungin | 13.5 | 97.3 | 100.0 | Â | Â | Â | Â | Â | Â | Â | Â |
| Â | Â | Micafungin | Â | 5.4 | 40.5 | 100.0 | Â | Â | Â | Â | Â | Â | Â |
C. famata | 24 | Anidulafungin | Â | 4.2 | 16.7 | 20.8 | 20.8 | 20.8 | 25.0 | 50.0 | 100.0 | Â | Â |
| Â | Â | Caspofungin | Â | 4.2 | 12.5 | 20.8 | 37.5 | 70.8 | 70.8 | 95.8 | 100.0 | Â | Â |
| Â | Â | Micafungin | Â | 4.2 | 16.7 | 16.7 | 20.8 | 33.3 | 75.0 | 91.7 | 100.0 | Â | Â |
Candida spp. | 30 | Anidulafungin | 3.3 | 30.0 | 50.0 | 63.3 | 63.3 | 73.3 | 86.7 | 93.3 | 96.7 | 96.7 | 100.0 |
| Â | Â | Caspofungin | Â | 16.7 | 43.3 | 63.3 | 73.3 | 96.7 | 100.0 | Â | Â | Â | Â |
| Â | Â | Micafungin | Â | 20.0 | 53.3 | 66.7 | 66.7 | 86.7 | 100.0 | Â | Â | Â | Â |
Total | 5,246 | Anidulafungin | 3.7 | 21.1 | 48.9 | 72.6 | 82.0 | 83.4 | 84.7 | 88.7 | 98.8 | 99.9 | 100.0 |
| Â | Â | Caspofungin | 1.2 | 19.7 | 59.4 | 79.6 | 84.0 | 91.9 | 98.1 | 99.7 | 99.9 | 99.9 | 100.0 |
| Â | Â | Micafungin | 8.8 | 60.9 | 75.6 | 81.3 | 83.3 | 85.0 | 88.5 | 97.0 | 100.0 | Â | Â |