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Table 5 In vitro susceptibilities of 5,346 clinical isolates of Candida spp. to anidulafungin, caspofingin, and micafungin [38].

From: Epidemiology and antifungal resistance in invasive candidiasis

Organism No. of isloates tested Antifungal agent   Cumulative % of isolates susceptible at a MIc (μg/ml) ofa   
    0.007 0.015 0.03 0.06 0.12 0.25 0.5 1 2 4 ≥8
C. albicans 2,869 Anidulafungin 6.2 33.5 69.5 92.4 99.1 99.5 99.5 99.6 100.0   
   Caspofungin 1.7 26.7 74.2 97.1 99.3 99.9 100.0     
   Micafungin 11.9 80.6 96.4 99.3 99.4 99.5 99.6 100.0    
C. parapsilosis 759 Anidulafungin    0.3 0.3 0.3 1.4 4.7 27.9 92.5 100.0  
   Caspofungin   0.1 0.5 3.3 10.7 52.2 89.5 98.6 99.9 100.0  
   Micafungin   0.1 0.3 0.3 0.5 6.1 24.4 79.3 100.0   
C. glabrata 747 Anidulafungin   0.4 7.8 62.4 93.6 99.4 99.7 99.9 99.9 100.0  
   Caspofungin   7.0 65.2 95.3 98.4 99.2 99.7 99.9 99.9 99.9 100.0
   Micafungin 13.7 91.4 97.9 98.9 99.5 99.9 99.9 100.0    
C. tropicalis 625 Anidulafungin 3.2 24.2 75.7 95.0 98.4 99.4 99.5 99.5 100.0   
   Caspofungin 1.3 31.0 79.7 97.3 99.0 99.7 99.7 99.8 99.8 99.8 100.0
   Micafungin 4.0 39.5 77.6 96.3 98.6 99.5 99.7 100.0    
C. krusei 136 Anidulafungin   2.9 47.1 90.4 99.3 99.3 100.0     
   Caspofungin   0.7 0.7 41.9 75.7 94.9 99.3 100.0    
   Micafungin   2.2 13.2 85.3 96.3 100.0      
C. guilliermondii 61 Anidulafungin      3.3 6.6 13.1 57.4 90.2 100.0  
   Caspofungin    1.6 4.9 11.5 39.3 80.3 95.1 95.1 95.1 100.0
   Micafungin   3.3 3.3 6.6 11.5 21.3 65.6 98.4 100.0   
C. lusitaniae 58 Anidulafungin     1.7 13.8 43.1 96.6 100.0    
   Caspofungin    3.4 6.9 44.8 89.7 96.6 100.0    
   Micafungin    1.7 8.6 63.8 96.6 98.3 100.0    
C. kefyr 37 Anidulafungin   2.7 10.8 56.8 100.0       
   Caspofungin 13.5 97.3 100.0         
   Micafungin   5.4 40.5 100.0        
C. famata 24 Anidulafungin   4.2 16.7 20.8 20.8 20.8 25.0 50.0 100.0   
   Caspofungin   4.2 12.5 20.8 37.5 70.8 70.8 95.8 100.0   
   Micafungin   4.2 16.7 16.7 20.8 33.3 75.0 91.7 100.0   
Candida spp. 30 Anidulafungin 3.3 30.0 50.0 63.3 63.3 73.3 86.7 93.3 96.7 96.7 100.0
   Caspofungin   16.7 43.3 63.3 73.3 96.7 100.0     
   Micafungin   20.0 53.3 66.7 66.7 86.7 100.0     
Total 5,246 Anidulafungin 3.7 21.1 48.9 72.6 82.0 83.4 84.7 88.7 98.8 99.9 100.0
   Caspofungin 1.2 19.7 59.4 79.6 84.0 91.9 98.1 99.7 99.9 99.9 100.0
   Micafungin 8.8 60.9 75.6 81.3 83.3 85.0 88.5 97.0 100.0   
  1. a Values corresponding to MIcs at which at least 90% of isolates are inhibited are listed in bold types.