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Table 7 Antifungal susceptibilities of rare Candida bloodstream isolates [41].

From: Epidemiology and antifungal resistance in invasive candidiasis

Species

No. of isolates

Antifungal agent

No. inhibited at MIC (μg/ml) of:

   

0.007

0.015

0.03

0.06

0.12

0.25

0.5

1

2

4

8

16 b

32

64 c

≥128

C. lasitaniae

171

Amphotericina

   

3

18

74

66

7

1

0

1

1

   
 

171

Fluconazole

    

20

52

64

20

5

3

1

1

3

2

 
 

171

Posaconazole

2

25

63

58

15

4

1

3

       
 

171

Voriconazole

123

33

3

4

2

3

2

1

       
 

96

Anidulafungin

   

5

13

36

40

2

       
 

166

Caspofungin

 

1

4

6

68

66

17

3

0

1

     
 

80

Micafungin

1

0

4

8

44

21

1

1

       

C. guilliermondii

174

Amphotericin

1

0

1

8

63

62

24

6

2

1

1

0

0

5

 
 

175

Fluconazole

     

1

4

4

69

68

13

7

2

3

4

 

175

Posaconazole

 

1

9

10

44

73

25

3

4

0

0

6

   
 

175

Voriconazole

2

11

19

83

43

8

1

0

2

0

0

6

   
 

107

Anidulafungin

 

1

 

2

6

5

7

37

41

8

     
 

156

Caspofungin

  

2

9

21

33

58

21

4

2

2

4

   
 

96

Micafungin

 

3

1

4

10

13

33

27

4

0

0

1

   

C. orthopsilosis

102

Amphotericin

     

7

29

35

23

8

     
 

102

Fluconazole

     

6

28

45

9

8

4

1

0

1

 
 

102

Posaconazole

 

1

12

40

30

8

11

        
 

102

Voriconazole

1

24

40

24

1

10

1

1

       
 

52

Anidulafungin

     

3

12

28

9

      
 

91

Caspofungin

1

0

3

17

37

25

8

        
 

51

Micafungin

    

2

25

21

3

       

C. kefyr

74

Amphotericin

      

20

43

10

0

0

0

0

1

 
 

74

Fluconazole

    

11

44

12

6

1

      
 

74

Posaconazole

1

3

17

21

23

8

1

        
 

74

Voriconazole

50

18

4

2

           
 

58

Anidulafungin

 

1

5

31

21

          
 

74

Caspofungin

11

56

6

1

           
 

53

Micafungin

 

4

2

26

1

          

C. pelliculosa

40

Amphotericin

    

3

14

21

2

       
 

40

Fluconazole

       

2

7

24

7

    
 

40

Posaconazole

   

1

1

6

4

14

12

2

     
 

40

Voriconazole

 

1

1

1

21

13

3

        
 

14

Anidulafungin

2

9

2

1

           
 

37

Caspofungin

1

16

17

3

           
 

14

Micafungin

 

5

7

2

           

C. famata

16

Amphotericin

    

1

6

8

0

0

1

     
 

16

Fluconazole

       

1

5

6

1

3

   
 

16

Posaconazole

 

2

0

0

1

5

7

1

2

      
 

16

Voriconazole

  

2

5

4

3

0

1

1

      
 

16

Anidulafungin

   

2

0

0

0

5

9

      
 

16

Caspofungin

  

1

2

2

5

3

2

1

      
 

16

Micafungin

  

1

1

0

2

5

5

2

      

C. metapsilosis

30

Amphotericin

    

1

5

12

9

2

1

     
 

30

Fluconazole

     

1

0

19

9

1

     
 

30

Posaconazole

 

1

7

15

5

1

0

1

       
 

30

Voriconazole

1

4

22

2

1

          
 

11

Anidulafungin

     

5

3

2

1

      
 

24

Caspofungin

  

1

5

14

3

0

1

       
 

11

Micafungin

     

7

3

1

       

C. dubliniensis

18

Amphotericin

   

1

8

7

1

1

       
 

18

Fluconazole

    

8

9

0

0

0

0

1

    
 

18

Posaconazole

 

4

6

7

1

          
 

18

Voriconazole

11

5

2

            
 

11

Anidulafungin

  

7

2

0

2

         
 

17

Caspofungin

 

2

6

9

           
 

9

Micafungin

 

4

3

2

           

C. lipolytica

16

Amphotericin

      

1

5

5

4

1

    
 

16

Fluconazole

      

1

1

6

6

1

0

0

1

 
 

16

Posaconazole

    

2

1

8

4

0

1

     
 

16

Voriconazole

 

1

5

7

2

0

0

1

       
 

10

Anidulafungin

     

3

4

2

1

      
 

15

Caspofungin

    

6

9

         
 

10

Micafungin

     

6

3

1

       

C. rugosa

16

Amphotericin

      

4

3

7

1

0

0

0

1

 
 

16

Fluconazole

      

1

0

4

3

2

4

1

1

 
 

16

Posaconazole

   

6

2

5

3

        
 

16

Voriconazole

2

1

4

3

1

3

2

        
 

16

Anidulafungin

   

3

1

4

3

3

0

0

2

    
 

16

Caspofungin

  

1

1

0

1

2

8

0

1

0

2

   
 

16

Micafungin

  

1

3

3

5

2

0

0

0

0

2

   
  1. aAmphoiericin B MICs were determined by EtesL
  2. bFor posaconazole. voriconazole, anidulafungin. caspofungin. and micafungin. isolates for which MICs are reported to be 16 μg/ml encompass all isolates for which MICs were > 8 μg/ml.
  3. cFor amphotericin B. isolates for which the MIC is reported to be 64 μg/ml encompass all isolates for which MICs were > 32 μg/ml.
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European Journal of Medical Research

ISSN: 2047-783X

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