Figure 7

Patient 2. a), b) Diffuse large B-cell lymphoma within the central nervous tissue penetrating a blood vessel. c) The large tumor cells express the B-cell marker CD20 and reveal a high proliverative activity d). Patient 1. e) In a further case H&E stained section shows a diffuse large B-cell lymphoma. Nearly all of the lymphoma cells show prominent central nucleoli. f) The tumor cells are reactive with antibodies against CD20. g) The mature T-cell react with antibodies against CD3. h) The proliferation marker MiB1 (Ki67) labels more than 50% of the tumor cells. Patient 3. i, j) The H&E stained sections reveal necrotic cns tissue with reactive astrocytes, macrophages and inflammatory cells. k) With antibodies against CD20 some blastic B-cells where detectable. l) The proliferation marker Mib1 labels only some inflammatory cells.