Skip to main content

Table 1 Plasma parameters in rats with D-galactosamine-induced acute liver failure with or without SLV338 treatment

From: Dual endothelin-converting enzyme/neutral endopeptidase blockade in rats with D-galactosamine-induced liver failure

  Con Con+SLV GalN GalN+SLV
N 9 9 19 22
Aspartate aminotransferase (U/I) 266 ± 27 185 ± 11* 5802 ± 1299** 5743 ± 1217**
Alanine aminotransferase (U/I) 46 ± 7 40 ± 2 2937 ± 700*** 2970 ± 592***
Gamma-glutamyl transferase (U/I) 2.0 ± 0.01 4.3 ± 2 8.4 ± 2** 9.2 ± 1**
Bilirubin (mg/dl) 0.1 ± 0.01 0.1 ± 0.01 3.2 ± 0.6** 3.7 ± 0.6***
Cholinesterase (U/l) 96 ± 14 105 ± 14 94 ± 8 87 ± 9
Total protein (g/dl) 5.0 ± 0.1 5.0 ± 0.1 4.2 ± 0.1*** 4.2 ± 0.2**
Glucose (mg/dl) 159 ± 7 168 ± 7 89 ± 13*** 94 ± 12**
Creatinine (mg/dl) 0.27 ± 0.02 0.40 ± 0.13 0.33 ± 0.02 0.35 ± 0.03*
Urea (mg/dl) 37 ± 3 36 ± 6 43 ± 2 44 ± 5
Sodium (mmol/l) 143 ± 0.9 142 ± 0.6 141 ± 0.4 141 ± 0.6
Lipase (U/I) 8.3 ± 0.5 9.1 ± 0.2 18.2 ± 7.6 11.0 ± 1.4
Creatine kinase (U/I) 1891 ± 169 1135 ± 90** 2687 ± 1483* 866 ± 108***
Big endothelin-1 / Endothelin-1 13.7 ± 7.0 12.5 ± 7.4 8.4 ± 3.5 18.0 ± 14
SLV338 (μg/l) 0 ± 0 703 ± 230 0 ± 0 545 ± 88
  1. Con, controls; SLV, SLV338; GalN, D-galactosamine.
  2. Data are means ± standard error of the mean.
  3. *p < 0.05, **p < 0.01, ***p < 0.001 vs. Con.