| |
Con
|
Con+SLV
|
GalN
|
GalN+SLV
|
|---|
|
N
|
9
|
9
|
19
|
22
|
|
Aspartate aminotransferase (U/I)
|
266 ± 27
|
185 ± 11*
|
5802 ± 1299**
|
5743 ± 1217**
|
|
Alanine aminotransferase (U/I)
|
46 ± 7
|
40 ± 2
|
2937 ± 700***
|
2970 ± 592***
|
|
Gamma-glutamyl transferase (U/I)
|
2.0 ± 0.01
|
4.3 ± 2
|
8.4 ± 2**
|
9.2 ± 1**
|
|
Bilirubin (mg/dl)
|
0.1 ± 0.01
|
0.1 ± 0.01
|
3.2 ± 0.6**
|
3.7 ± 0.6***
|
|
Cholinesterase (U/l)
|
96 ± 14
|
105 ± 14
|
94 ± 8
|
87 ± 9
|
|
Total protein (g/dl)
|
5.0 ± 0.1
|
5.0 ± 0.1
|
4.2 ± 0.1***
|
4.2 ± 0.2**
|
|
Glucose (mg/dl)
|
159 ± 7
|
168 ± 7
|
89 ± 13***
|
94 ± 12**
|
|
Creatinine (mg/dl)
|
0.27 ± 0.02
|
0.40 ± 0.13
|
0.33 ± 0.02
|
0.35 ± 0.03*
|
|
Urea (mg/dl)
|
37 ± 3
|
36 ± 6
|
43 ± 2
|
44 ± 5
|
|
Sodium (mmol/l)
|
143 ± 0.9
|
142 ± 0.6
|
141 ± 0.4
|
141 ± 0.6
|
|
Lipase (U/I)
|
8.3 ± 0.5
|
9.1 ± 0.2
|
18.2 ± 7.6
|
11.0 ± 1.4
|
|
Creatine kinase (U/I)
|
1891 ± 169
|
1135 ± 90**
|
2687 ± 1483*
|
866 ± 108***
|
|
Big endothelin-1 / Endothelin-1
|
13.7 ± 7.0
|
12.5 ± 7.4
|
8.4 ± 3.5
|
18.0 ± 14
|
|
SLV338 (μg/l)
|
0 ± 0
|
703 ± 230
|
0 ± 0
|
545 ± 88
|
- Con, controls; SLV, SLV338; GalN, D-galactosamine.
- Data are means ± standard error of the mean.
- *p < 0.05, **p < 0.01, ***p < 0.001 vs. Con.
