Table 1 Plasma parameters in rats with D-galactosamine-induced acute liver failure with or without SLV338 treatment
Con | Con+SLV | GalN | GalN+SLV | |
|---|---|---|---|---|
N | 9 | 9 | 19 | 22 |
Aspartate aminotransferase (U/I) | 266 ± 27 | 185 ± 11* | 5802 ± 1299** | 5743 ± 1217** |
Alanine aminotransferase (U/I) | 46 ± 7 | 40 ± 2 | 2937 ± 700*** | 2970 ± 592*** |
Gamma-glutamyl transferase (U/I) | 2.0 ± 0.01 | 4.3 ± 2 | 8.4 ± 2** | 9.2 ± 1** |
Bilirubin (mg/dl) | 0.1 ± 0.01 | 0.1 ± 0.01 | 3.2 ± 0.6** | 3.7 ± 0.6*** |
Cholinesterase (U/l) | 96 ± 14 | 105 ± 14 | 94 ± 8 | 87 ± 9 |
Total protein (g/dl) | 5.0 ± 0.1 | 5.0 ± 0.1 | 4.2 ± 0.1*** | 4.2 ± 0.2** |
Glucose (mg/dl) | 159 ± 7 | 168 ± 7 | 89 ± 13*** | 94 ± 12** |
Creatinine (mg/dl) | 0.27 ± 0.02 | 0.40 ± 0.13 | 0.33 ± 0.02 | 0.35 ± 0.03* |
Urea (mg/dl) | 37 ± 3 | 36 ± 6 | 43 ± 2 | 44 ± 5 |
Sodium (mmol/l) | 143 ± 0.9 | 142 ± 0.6 | 141 ± 0.4 | 141 ± 0.6 |
Lipase (U/I) | 8.3 ± 0.5 | 9.1 ± 0.2 | 18.2 ± 7.6 | 11.0 ± 1.4 |
Creatine kinase (U/I) | 1891 ± 169 | 1135 ± 90** | 2687 ± 1483* | 866 ± 108*** |
Big endothelin-1 / Endothelin-1 | 13.7 ± 7.0 | 12.5 ± 7.4 | 8.4 ± 3.5 | 18.0 ± 14 |
SLV338 (μg/l) | 0 ± 0 | 703 ± 230 | 0 ± 0 | 545 ± 88 |