Table 3 Efficacy of different classes of anti-HCV agents with respect to resistance profile, genotype coverage and antiviral activity
| Â | NS3 Protease Inhibitors | NS5A Inhibitors | NS5B Nuc. Inhibitors | NS5B Non-Nuc. Inhibitors | Cyclophilin Inhibitors | PEG-Interferon alfa |
|---|---|---|---|---|---|---|
Barrier to resistance | low | low | high | low | high | very high |
Genotype coverage | + | ++ | +++ | - | ++ | +++ |
antiviral activity | +++ | +++ | ++ | ++ | +/++ | + |