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Table 2 Differences between patients with rs12979860 C/T genotypes in the cross-sectional analysis.

From: Progression of liver fibrosis in HIV/HCV genotype 1 co-infected patients is related to the T allele of the rsI2979860 polymorphism of the IL28B gene

 

CC

CT

TT

P

Patients

42 (50%)

36 (43%)

6 (7%)

 

Stiffness [kPa]

11.0 ± 8.6

13.2 ± 11.8

11.2 ± 11.9

n.s.

APRI score (median, range)

2.7 ± 7.1 (0.9; 0.3 - 43.2)

1.4 ± 1.2 (0.8; 0.4 - 5.7)

1.1 ± 0.6 (1.3; 0.5 - 1]

n.s.

FIB-4 score (median, range)

3.8 ± 8.2 (1.6; 0.5 - 50,3)

2.2 ± 2.0 (1.5; 0.7 - 10.7)

2.2 ± 1.3 (1.6; 0.9 - 3.8)

n.s.

ast [U/I]

65 ± 41

57 ± 33

64 ± 39

n.s.

ALT [U/l]

84 ± 52

74 ± 47

94 ± 87

n.s.

Thrombocytes [T/l]

163 ± 77

157 ± 5

181 ± 55

n.s.

HCV-load

   

n.s.

Undetectable:

9 (21%)

5 (14%)

  

low (< 800000 IU/1)

6 (14%)

8 (23%)

  

high (> 800000 1 U/1)

27 (64%)

22 (63°/.)

6 (100%)

 

HCV-genotype

   

p = 0.03

1

20 (54%)

29 (88%)

3 (60%)

 

2

5 (14%)

1 (3%)

  

3

10(27%)

2 (6%)

1 (20%.)

 

4

2 (5%)

1 (3%)

1 (20%)

 

HAART

34(81%)

31(86%)

4(67%)

n.s.

CD4 [cells/μl] (median, range)

428 (52 - 1757)

366 (10 - 966)

268 (85 - 1056)

 
 

428 (52 - 1757)

356 (10 - 1056)

p = 0.02

< 50 HIV copies/ml

35 (83%)

23 (64%)

4 (67%)

n.s.