Multiple anti-glycan antibodies detectable in CF patients. a-e, Comparison of anti-glycan antibodies (% of sera positive results ± CI 95%) for patients with cystic fibrosis (CF, a), Crohn's disease (CD, b), ulcerative colitis (UC, C), rheumatoid arthritis (RA, d), as well as healthy volunteers (HC, e). Positive anti-glycan titer were defined as ≥ 50 U/ml. X-axis indicates patients positive for gASCA alone, or positive for gASCA+ ≥ 1Ab or gASCA+ ≥ 2Ab at the time, respectively. Patients positive for gASCA and ≥ 2 anti-glycan markers were only found in CF and CD, but not in any of the other groups.