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Table 2 Performance characteristics of anti-glycan antibodies for detection of patients with Crohn's disease

From: Increased levels of anti-glycan antibodies in patients with cystic fibrosis

 

SE

SP

PPV

NPV

ACC

gASCA only

76.5

91.8

86.7

84.9

85.5

gASCA+1Ab

41.2

95.9

87.5

70.1

73.5

gASCA+2Ab

17.6

100

100.0

63.6

66.3

gASCA+3Ab

2.9

100

100.0

59.8

60.2

  1. SE = sensitivity; SP = specificity; PPV = positive predictive value; NPV = negative predictive value; ACC = accuracy; Ab anti-glycan antibodies (ACCA, ALCA, AMCA). Sera positive antibody titers were defined as ≥ 50 U/ml.