Microbiological safety of a novel bio-artificial liver support system based on porcine hepatocytes: a experimental study

Table 3 Reverse transcriptasde activity of the plasma at defined time intervals

Time point	Beagle
Time point	1	2	3	4	5
Pre-treatment in circuit 3	Positive*	Positive*	Positive*	Positive*	Positive*
After 3 hours of treatment in circuit 3	Positive*	Negative	Negative	Positive	Negative
After 6 hours of treatment in circuit 3	Negative	Negative	Negative	Negative	Negative
Pre-treatment in circuit 2	Negative	Negative	Negative	Negative	Negative
After 3 hours of treatment in circuit 2	Negative	Negative	Negative	Negative	Negative
After 6 hours of treatment in circuit 2	Negative	Negative	Negative	Negative	Negative
Pre-treatment in circuit 1	Negative	Negative	Negative	Negative	Negative
After 3 hours of treatment in circuit 1	Negative	Negative	Negative	Negative	Negative
After 6 hours of treatment in circuit 1	Negative	Negative	Negative	Negative	Negative
Pre-treatment in circuit 1	Negative	Negative	Negative	Negative	Negative
3 hours after treatment	Negative	Negative	Negative	Negative	Negative
12 hours after treatment	Negative	Negative	Negative	Negative	Negative
24 hours after treatment	Negative	Negative	Negative	Negative	Negative
3 days after treatment	Negative	Negative	Negative	Negative	Negative
5 days after treatment	Negative	Negative	Negative	Negative	Negative
7 days after treatment	Negative	Negative	Negative	Negative	Negative
2 weeks after treatment	Negative	Negative	Negative	Negative	Negative
1 month after treatment	Negative	Negative	Negative	Negative	Negative
3 months after treatment	Negative	Negative	Negative	Negative	Negative
6 months after treatment	Negative	Negative	Negative	Negative	Negative

ISSN: 2047-783X