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Table 1 Patient profiles for 17 patients presenting symptomatic radiation necrosis

From: Reversal of cerebral radiation necrosis with bevacizumab treatment in 17 Chinese patients

Pt. No

Age (y)

Sex

Underlying disease

Radiation treatment

Radiation necrosis site

Last RT to study entry (mo)

% Change in Gadolinium

% Change in T2W

Radiologic follow-up

KPS*#

Steroids**# (mg)

1

70

M

Colon cancer

SRS 17 Gy

Left temporal

6

0

0

4

30 → 30

15 → 12.5

2

13

F

Anaplastic Astrocytoma

EBRT 56 Gy

Right thalamus

18

75

60

9

50 → 70

10 → 0

3

71

M

Colon cancer

EBRT 36 Gy

Left frontal

4

65

10

6

40 → 80

15 → 5

4

52

F

meningioma

EBRT 60 Gy

Right frontal

180

80

60

8

60 → 90

10 → 2.5

5

71

M

Lung cancer

FSRT 31.5 Gy/3 fx

Left occipital

7

87

78

8

50 → 90

15 → 0

6

48

M

Glioblastoma

EBRT 60 Gy

Left frontal

7

80

75

5

50 → 70

10 → 2.5

7

32

F

Anaplastic oligodendroglioma

EBRT 60 Gy

Right frontal

40

50

45

4

50 → 70

15 → 10

8

67

F

Colon cancer

1.EBRT 39 Gy /13 fx

Right frontal

1

52

78

4

50 → 90

15 → 0

2.SRS 16 Gy

9

23

M

AVM

SRS 16 Gy

Left basal ganglia

21

50

40

3

70 → 80

10 → 5

10

26

M

Fibrous dysplasia of bone

EBRT 70 Gy

Brain stem

132

65

55

4

50 → 70

17.5 → 5

11

62

M

Glioblastoma

EBRT 60 Gy

Left frontal

9

73

61

8

30 → 50

15 → 5

12

65

M

Glioblastoma

EBRT 60 Gy

Right frontal

4

30

45

6

60 → 70

10 → 2.5

13

41

M

Glioblastoma

FSRT 30 Gy/6 fx

Left basal ganglia

15

60

50

8

50 → 90

15 → 2.5

14

45

M

Glioblastoma

FSRT 25.2 Gy/6 fx

Right thalamus

4

33

76

6

60 → 90

15 → 2.5

15

46

M

Lung cancer

1.EBRT 30 Gy/10 fx

Left occipital

5

50

30

8

60 → 80

12.5 → 5

2.SRS 16 Gy

16

34

M

Glioblastoma

EBRT 60 Gy

Right temporal

5

75

54

4

60 → 80

15 → 5

17

55

M

Glioblastoma

EBRT 56 Gy

Right temporal

6

60

65

8

40 → 60

10 → 0

  1. Abbreviations: AVM, arteriovenous malformation; EBRT, external beam radiation therapy; F, female; FSRT, fractionated stereotactic radiotherapy; KPS, Karnofsky performance status; M, male; RT, radiation treatment; SRS, stereotactic radiosurgery; T2W, T2-weighted MRI.
  2. Note: * Karnofsky performance scores were assessed immediately prior to treatment and at four weeks after treatment initiation.
  3. ** Amounts of dexamethasone (mg/day) immediately prior to the treatment and four weeks after treatment initiation.
  4. # pretreatment → post two injections of bevacizumab.