Figure 4
Gene expression in animal models inoculated with high-metastatic hepatocellular carcinoma cell 97 (MHCC97-H) cells before and after human mesenchymal stem cell (hMSC) engraftment. (A) The expression of metastasis-related factor osteopontin (OPN) by the tumor tissue specimen over time. (B) The expression of metastasis-related factor bone sialoprotein (BSP) by the tumor tissue specimen over time. (C) The expression of metastasis-related factor integrin α5 subunit (α-V) by the tumor tissue specimen over time. (D) The expression of antiapoptotic gene B cell lymphoma/leukemia-2 (Bcl2) by the tumor tissue specimen over time (note: negative is the control group). (E, F) The expression of apoptotic gene Bcl-2 associated X protein (Bax) and caspase 3 by the tumor tissue specimen over time (note: negative is the control group).