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Table 3 Frequencies of MTHFR C677T polymorphisms in childhood ALL patients and controls

From: Association of methylenetetrahytrofolate reductase (MTHFR) C677T and A1298C polymorphisms with the susceptibility of childhood acute lymphoblastic leukaemia (ALL) in Chinese population

MTHFR C677T

Patient no. (%)

Control no. (%)

χ2

P

OR (95%CI)

Genotype

     

CC

28 (28.6)

29 (31.2)

 

-

1.00#

CT

44 (44.9)

49 (52.7)

0.046

0.829

0.930 (0.481 - 1.799)

TT

26 (26.5)

15 (16.1)

1.969

0.161

1.795 (0.790 - 4.079)

CT + TT

70 (71.4)

64 (68.8)

0.155

0.693

1.133 (0.609 - 2.106)

Allele

     

C

100 (51.0)

107 (57.5)

 

-

1.00#

T

96 (49.0)

79 (42.5)

1.627

0.202

1.300 (0.868 - 1.947)

  1. #As reference group; OR, crude odds ratio; —, not applicable; CI, confidence interval. CC, CT and TT overall distribution test, χ2test = 3.109, P = 0.211.