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Table 4 Frequencies of MTHFR A1298C polymorphisms in childhood ALL patients and controls

From: Association of methylenetetrahytrofolate reductase (MTHFR) C677T and A1298C polymorphisms with the susceptibility of childhood acute lymphoblastic leukaemia (ALL) in Chinese population

MTHFR A1298C Patient no. (%) Control no. (%) χ2* P OR (95%CI)
Genotype      
AA 54 (55.1) 67 (72.0)   - 1.00#
AC 42 (42.9) 25 (26.9) 5.628 0.018 2.084 (1.131 - 3.841)
CC 2 (2.0) 1 (1.1) 0.574 0.449 2.481 (0.219 - 28.104)
AC + CC 44 (44.9) 26 (28.0) 5.898 0.015 2.100 (1.149 - 3.837)
Allele      
A 150(76.5) 159 (85.5)   - 1.00#
C 46(23.5) 27 (14.5) 4.949 0.026 1.806 (1.068 - 3.053)
  1. *Corrected chi-square test; #as reference group; OR, crude odds ratio; —, not applicable; CI, confidence interval. AA, AC and CC overall distribution test, χ2test = 5.917, P = 0.05.