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Table 4 Frequencies of MTHFR A1298C polymorphisms in childhood ALL patients and controls

From: Association of methylenetetrahytrofolate reductase (MTHFR) C677T and A1298C polymorphisms with the susceptibility of childhood acute lymphoblastic leukaemia (ALL) in Chinese population

MTHFR A1298C

Patient no. (%)

Control no. (%)

χ2*

P

OR (95%CI)

Genotype

     

AA

54 (55.1)

67 (72.0)

 

-

1.00#

AC

42 (42.9)

25 (26.9)

5.628

0.018

2.084 (1.131 - 3.841)

CC

2 (2.0)

1 (1.1)

0.574

0.449

2.481 (0.219 - 28.104)

AC + CC

44 (44.9)

26 (28.0)

5.898

0.015

2.100 (1.149 - 3.837)

Allele

     

A

150(76.5)

159 (85.5)

 

-

1.00#

C

46(23.5)

27 (14.5)

4.949

0.026

1.806 (1.068 - 3.053)

  1. *Corrected chi-square test; #as reference group; OR, crude odds ratio; —, not applicable; CI, confidence interval. AA, AC and CC overall distribution test, χ2test = 5.917, P = 0.05.
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European Journal of Medical Research

ISSN: 2047-783X

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