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Figure 1 | European Journal of Medical Research

Figure 1

From: The secondary structure of the TGR5 membrane-proximal C-terminus determines plasma membrane localization and responsiveness towards extracellular ligands

Figure 1

A Clustering results of the TGR5 C-terminus WT and mutants according to the secondary structure sequence. The numbers indicate how many percent of the conformations of each variant are found in the respective cluster. B Membrane localization and function of the TGR5 C-terminus WT and mutants. The membrane localization was determined by FACS assay; the function was determined by cAMP reporter gene assay (n > 8). C Secondary structure content, membrane localization, and function of the TGR5β2AR chimera variants. The secondary structure content was averaged over all residues and over the simulation time; the membrane localization was determined by FACS assay; the function was determined by a cAMP reporter gene assay (n > 8). Panels adapted from ref. [3].

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