Subgroup of tumor size | Sample size | No. of studies | Meta-analysis | Test of heterogeneity | Egger's test | |||
---|---|---|---|---|---|---|---|---|
Case | Control | OR (95% CI) | Pvalue | Pvalue | I2(%) | Pvalue | ||
Cancer-specific death | ||||||||
Overall | 6,275 | 2,457 | 1.58 (1.15 to 2.15) | 0.004 | 0.22 | 30.0 | 0.27 | |
≤4.0 cm | 3,930 | 1,191 | 1.86 (1.11 to 3.13) | 0.002 | 0.17 | 41 | – | |
>4.0 cm | 2,345 | 1,266 | 1 [20] | 1.36 (1.01 to 1.85) | 0.04 | – | – | – |
Tumor recurrence | ||||||||
Overall | 3,701 | 1,857 | 0.84 (0.67 to 1.06) | 0.14 | 0.43 | 0.0 | 0.58 | |
≤4.0 cm | 1,290 | 558 | 0.67 (0.27 to 1.64) | 0.38 | 0.16 | 45 | – | |
>4.0 cm | 2,411 | 1,299 | 0.87 (0.36 to 2.11) | 0.76 | 0.68 | 0 | – | |
Complications | ||||||||
Overall | 826 | 682 | 0.91 (0.51 to 1.63) | 0.74 | <0.01 | 71.0 | 0.76 | |
≤4.0 cm | 488 | 477 | 1.10 (0.31 to 3.92) | 0.88 | 0.0004 | 87 | – | |
>4.0 cm | 265 | 191 | 0.71 (0.44 to 1.13) | 0.15 | 0.88 | 0 | – |