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Table 3 Genetic polymorphisms of glutathione S-transferase (GST) M1 and T1 in relation to plasma MDA, NO and T-AOC

From: Genetic polymorphisms of glutathione S-transferase M1 and T1, and evaluation of oxidative stress in patients with non-small cell lung cancer

Group

N

MDA (nmo/lmL)

NO (nmol/mL)

T-AOC (units/mL)

Control

100

8.49 ± 3.30

16.79 ± 5.37

13.69 ± 4.56

Case

110

11.67 ± 4.31

19.68 ± 4.11

9.88 ± 3.58

P

 

<0.001

<0.001

<0.001

GSTM1

    

(+)

44

10.18 ± 4.23

18.01 ± 3.56

11.11 ± 2.67

(-)

66

12.67 ± 4.09

20.80 ± 4.09

9.07 ± 3.88

P

 

<0.001a; 0.003b

<0.001a; <0.001b

<0.001a; 0.001b

GSTT1

    

(+)

35

9.29 ± 2.84

17.98 ± 3.99

11.73 ± 2.82

(-)

75

12.78 ± 4.44

20.48 ± 3.94

9.03 ± 3.58

P

 

<0.001a; <0.001c

<0.001a; 0.003c

<0.001a; <0.001c

GSTM1/T1

 

Control

Case

P

Control

Case

P

Control

Case

P

(+/+)

 

23

7.81 ± 2.97

20

8.56 ± 2.86

0.047

23

15.74 ± 4.38

20

17.68 ± 3.57

0.049

23

14.71 ± 4.29

23

11.97 ± 2.28

0.046

(+/-)

 

35

8.45 ± 3.01

24

11.52 ± 4.76

0.018

35

16.05 ± 5.13

24

18.28 ± 3.60

0.032

35

13.68 ± 4.79

35

10.39 ± 2.80

0.028

(-/+)

 

24

8.47 ± 2.98

15

10.27 ± 2.60

0.021

24

16.23 ± 4.90

15

18.37 ± 4.59

0.027

24

13.59 ± 4.92

24

11.40 ± 3.47

0.024

(-/-)

 

18

8.81 ± 3.12

51

13.38 ± 4.20

0.008

18

18.02 ± 4.29

51

21.51 ± 3.68

0.004

18

10.27 ± 5.01

18

8.39 ± 3.75

0.003

P

   

<0.001a; <0.001d

   

<0.001a; <0.001d

   

<0.001a; <0.001d

 
  1. +, present genotype; -, null genotype; MDA, malondialdehyde; NO, nitric oxide; T- AOC, total antioxidant capacity.
  2. acompared with control.
  3. bcompared with GSTM1 (+).
  4. ccompared with GSTT1 (+).
  5. dcompared with GSTM1/T1 (+/+).