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Figure 3 | European Journal of Medical Research

Figure 3

From: A panoramic spectrum of complex interplay between the immune system and IL-32 during pathogenesis of various systemic infections and inflammation

Figure 3

Mechanism of pathogenesis of inflammatory bowel disease (IBD). IBD pathogenesis is initiated by bacterial peptidoglycan, which induces caspase-1-dependent mechanism by NOD1 and NOD2, which enhanced the expression of IL-32. IL-32 initiates the NF-κB activation and a spectrum of various other inflammatory cytokines, and this activation ultimately result in IBD.

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