Figure 3From: A panoramic spectrum of complex interplay between the immune system and IL-32 during pathogenesis of various systemic infections and inflammation Mechanism of pathogenesis of inflammatory bowel disease (IBD). IBD pathogenesis is initiated by bacterial peptidoglycan, which induces caspase-1-dependent mechanism by NOD1 and NOD2, which enhanced the expression of IL-32. IL-32 initiates the NF-κB activation and a spectrum of various other inflammatory cytokines, and this activation ultimately result in IBD.Back to article page