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Table 1 Characteristics of included studies

From: Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis

Author Years Follow-up Intervention (mg) Comparator Age Female (%) BMI Duration Outcome
Pujalte JM 1980 8 weeks GS (1,500) Placebo 61.7 85 - - VAS, AR
Lopes VA 1982 8 weeks GS (1,500) NSAIDs 56.4 74 - 3.2 VAS, AR
Muller FH 1994 4 weeks GS (1,500) NSAIDs 54 42.3 - 4.8 Lequesne, AR
Noack W 1994 4 weeks GS (1,500) Placebo 55 60.3 - - Lequesne, AR
Nguyen M 1994 8 weeks D (50) NSAIDs, placebo 62 62.7 - 5.25 VAS, Lequesne, AR
Qiu GX 1998 4 weeks GS (1,500) NSAIDs 56.4 79 - - VAS, AR
Houpt JB 1999 8 weeks GH (1,500) Placebo 64.5 64.4 - 8.3 WOMAC, AR
Rindone JP 2000 4, 8 weeks GS (1,500) Placebo 63.5 5.1 - 13 VAS, AR
Pelletier JP 2000 24 weeks D (50, 100, 150) Placebo 62.8 76 31.28 7.9 VAS
Reginster JY 2001 3 years GS (1,500) Placebo 65.8 79.4 27.35 7.8 WOMAC, JSW, AR
Dougados M 2001 3 years D (100) Placebo 62.6 84 - - Lequesne, JSW
Hughes R 2002 6 months GS (1,500) Placebo 62.3 68 - 7.63 AR
Pavelka K 2002 1, 2, 3 years GS (1,500) Placebo 62.4 78.5 25.7 10.55 Lequesne, JSW, AR
Braham R 2003 3 months GS (2,000) Placebo 42.2 28.3 - 12.97 AR
Cibere J 2004 24 weeks GS (1,500) Placebo 64.5 57.7 25.26 1.6 AR
McAlindon T 2004 12 weeks GS (1,500) Placebo - 64 32.57 - WOMAC, AR
Pham T 2004 1 year D (100) Placebo 64.7 65.3 29.6 - Lequesne
Clegg DO 2006 24 weeks GS (1,500) Placebo, NSAIDs 58.7 42.2 31.73 10 WOMAC, AR
Zheng WJ 2006 12, 16 weeks D (100) NSAIDs 56.2 66.2 26.13 7.23 VAS, WOMAC, AR
Herrero-Beaumont G 2007 24 weeks GS (1,500) Placebo 63.9 88 27.65 7.31 Lequesne, AR
Louthrenoo W 2007 12, 24 weeks D (50) NSAIDs 54 73 26.85 3.58 WOMAC
Pavelka K 2007 12, 24 weeks D (50) Placebo 63.7 65.5 28.9 6.497 WOMAC, AR
Frestedt JL 2008 12 weeks GS (1,500) Placebo 59.1 60 32.24 - WOMAC, AR
Kawasaki T 2008 18 weeks GS (1,500) Placebo 68.9 - 23.95 - JSW
Rozendaal RM 2008 3, 12, 24 months GS (1,500) Placebo 63.4 69.4 27.95 - JSW, AR
Sawitzke AD 2008 2 months GS (1,500) Placebo, NSAIDs 50.6 55.7 - 8.52 JSW
Brahmachari B 2009 12 weeks D (50) Placebo 49.1 83.6 24.66 2.76 VAS, WOMAC, AR
Madhu K 2013 6 weeks GS (1,500) Placebo 56.8 70 27.9 - VAS, AR
Chopra A 2013 24 weeks GS (1,500) NSAIDs 55.5 - 27.7 - WOMAC, AR
Durmus D 2013 12 weeks GS (1,500) Placebo 55.8 - 27.7 - WOMAC
Kwoh CK 2014 24 weeks GS (1,500) Placebo 52.24 48.9 28.9 - WOMAC, AR
  1. AR = adverse event, BMI = body mass index, D = diacerein, GH = glucosamine hydrochloride, GS = glucosamine sulfate, JSW = joint space width, VAS = visual analog score.