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Table 3 Comparisons of treatment effects: a network meta-analysis

From: Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis

Treatment N Β P value 95% CI
Pain VAS score
  Glucosamine 195 −1.75 0.034* −3.32, −0.17
  NSAIDs 292 −1.74 0.047* −3.44, −0.03
  Diacerein 209 −1.78 0.024* −3.24, −0.32
  Placebo 187 0 - -
  Diacerein vs. glucosamine - −0.03 0.964 −1.58, 1.52
  NSAIDs vs. glucosamine - 0.01 0.988 −1.52, 1.54
  Diacerein vs. NSAIDs - −0.04 0.893 −0.72, 0.64
Total WOMAC score
  Glucosamine 73 17.70 0.367 −35.46, 70.87
  NSAIDs 79 −7.03 0.334 −26.51, 12.45
  Diacerein 164 −6.2 0.597 −39.69, 27.29
  Placebo 159 0 - -
  Diacerein vs. glucosamine - −23.90 0.218 −72.85, 25.06
  NSAIDs vs. glucosamine - −24.74 0.180 −69.91, 20.44
  Diacerein vs. NSAIDs - 0.84 0.899 −18.52, 20.20
Pain WOMAC score
  Glucosamine 408 1.47 0.139 −0.74, 3.68
  NSAIDs 164 −0.38 0.612 −2.31, 1.55
  Diacerein 397 −0.75 0.521 −3.75, 2.24
  Placebo 491 0 - -
  Diacerein vs. glucosamine - −2.22 0.078 −4.84, 0.39
  NSAIDs vs. glucosamine - −1.85 0.065 −3.88, 0.18
  Diacerein vs. NSAIDs - −0.376 0.643 −2.46, 1.71
Function WOMAC score
  Glucosamine 408 −2.42 0.534 −11.18, 6.33
  NSAIDs 503 1.53 0.463 −3.13, 6.20
  Diacerein 189 1.89 0.392 −3.02, 6.81
  Placebo 407 0 - -
  Diacerein vs. glucosamine - 4.32 0.436 −8.03, 16.67
  NSAIDs vs. glucosamine - 3.96 0.438 −7.43, 15.34
  Diacerein vs. NSAIDs - 0.36 0.913 −7.16, 7.89
Stiffness WOMAC score
  Glucosamine 390 −0.15 0.480 −0.66, 0.36
  NSAIDs 397 −0.77 0.207 −2.14, 0.60
  Diacerein 196 −0.89 0.097 −2.01, 0.23
  Placebo 499 0 - -
  Diacerein vs. glucosamine - −0.74 0.193 2.00, −0.52
  NSAIDs vs. glucosamine - 0.62 0.205 −1.71, 0.47
  Diacerein vs. NSAIDs - −0.12 0.788 −1.20, 0.96
Lequesne score change
  Glucosamine 214 −1.12 0.063 −2.36, 0.12
  Diacerein 75 0.03 0.970 −2.13, 2.18
  Placebo 192 0 - -
  Diacerein vs. glucosamine - 1.15 0.331 −4.32, 2.01
Joint space width change
  Glucosamine 357 −0.08 0.363 −0.31, 0.14
  Diacerein 246 0.12 0.207 −0.10, 0.34
  Placebo 597 0 - -
  Diacerein vs. glucosamine - −0.20 0.001* −0.27, −0.14
Adverse event N RR P value 95% CI
  Glucosamine 1,474 1.07 0.398 0.92, 1.23
  NSAIDs 814 2.20 <0.001* 1.56, 3.11
  Diacerein 381 1.91 <0.001* 1.36, 2.69
  Placebo 1,634 1 - -
  Diacerein vs. glucosamine - 1.80 0.001* 1.27, 2.55
  NSAIDs vs. glucosamine - 2.07 <0.001* 1.47, 2.91
  Diacerein vs. NSAIDs - 0.87 0.416 0.62, 1.22
Adverse event (GI)
  Glucosamine 1,850 0.84 0.103 0.68, 1.04
  NSAIDs 899 1.33 0.038* 1.02, 1.77
  Diacerein 1,345 1.44 <0.001* 1.24, 1.68
  Placebo 1,917 1 - -
  Diacerein vs. glucosamine - 1.72 <0.001* 1.34, 2.22
  NSAIDs vs. glucosamine - 1.60 0.004* 1.16, 2.19
  Diacerein vs. NSAIDs - 1.08 0.576 0.98, 1.50
  1. *Statistically significant difference (P < 0.05). CI = confidence interval, GI = gastrointestinal, NSAIDs = non-steroidal anti-inflammatory drugs, RR = relative risk, VAS = visual analog score, WOMAC = Western Ontario and McMaster Universities Osteoarthritis index.