Figure 3
From: microRNA-98 mediated microvascular hyperpermeability during burn shock phase via inhibiting FIH-1
Regulated role of miR-98 in FIH-1 expression in rat aorta endothelial cell. Knock down of miR-98 by miR-inhibitor (A) increased FIH 3ʹUTR activity, (B) suppressed HIF-1 expression, and (C) inactivated HIF-1 transcription. Overexpression of miR-98 by miR-98 mimic transfection (D) inhibited FIH 3ʹUTR activity, (E) promoted HIF-1 expression, and (F) increased HIF-1 transcription activity. The data were represented with mean ± SD. * P < 0.05 compared with negative control.