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Table 1 Characteristics of 70 patients diagnosed with large-cell neuroendocrine carcinoma of the lung

From: Outcome and prognostic factors of multimodal therapy for pulmonary large-cell neuroendocrine carcinomas

Factor LCNEC (n = 70)
Sex
 Male 52 (72 %)
 Female 18 (28 %)
Median age (range) 63 years (41–81)
 Over 70 years 20 (29 %)
 Under 70 years or 70 years 50 (71 %)
TNM stage (7th classification)
 IA/IB 9/10
 IIA/IIB 15/9
 IIIA/IIIB 18/2
 IVA/IVB 7
Thoracic surgery 66 (94 %)
 Primary 65 (93 %)
  Wedge resection 4 (6 %)
  Lobectomy 53 (81 %)
  Bilobectomy 3 (5 %)
  Pneumonectomy 5 (8 %)
Chemotherapy 36 (51 %)
 Definitive 4 (6 %)
 Adjuvant 32 (46 %)
 Relapse/progress 14 (20 %)
Thoracic radiotherapy 17 (24 %)
 Definitive 4 (6 %)
 Adjuvant/additive 10 (14 %)
 Relapse/progress 3 (4 %)
First line therapy brain metastases 17 (24 %)
 Resection 7 (10 %)
 Stereotactic irradiation 2 (3 %)
 Whole brain irradiation 6 (9 %)
 Best supportive care 2 (3 %)
Prophylactic cranial irradiation (PCI) 3 (4 %)