Skip to main content

Table 1 Treatment history and the changes of liver biochemical markers

From: Zoledronic acid-induced hepatotoxicity relieved after subsequent infusions in a Chinese woman with glucocorticoid-induced osteoporosis

Date Treatment ALT(U/L)
(5-40)
AST(U/L)
(5-37)
GGT(U/L)
(10-67)
TB(μmol/L)
(5.1-22.2)
DB(μmol/L)
(0-8.6)
ALP(U/L)
(30-120)
Symptoms
2012-4-12 ZOL infusion (5 mg) 33 15 45 9.8 2.6 77 Fever 38.7 °C, myalgia, arthralgia
2012-4-15 glucurolactone (100 mg 3/d), polyene ) 254 73 135 6.3 2.4  
2014-4-18 phosphatidylcholine (456 mg 3/d 126 43 112 7.7 2.5 118
2012-4-21   66 40 - 11.2 4.3  
2013-5-7 ZOL infusion (5 mg), glucurolactone (100 mg 3/d) 28 18 30 9.6 2.9 44 Fever 38.0 °C, arthralgia
2013-5-10   70 40 46 4.6 1.6 -  
2013-5-13 48 22 43 6.0 2.1 58  
2014-6-22 ZOL infusion (5 mg), glucurolactone (100 mg 3/d) 24 20 27 7.2 2.4 51 No fever or pain
2014-6-25   31 28 33 5.9 1.6 55  
  1. ALT alanine aminotransferase, AST aspartate aminotransferase, GGT gamma-glutamyltransferase, TB total bilirubin, DB direct bilirubin, ALP alkaline phosphatase