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Table 1 Treatment history and the changes of liver biochemical markers

From: Zoledronic acid-induced hepatotoxicity relieved after subsequent infusions in a Chinese woman with glucocorticoid-induced osteoporosis

Date

Treatment

ALT(U/L)

(5-40)

AST(U/L)

(5-37)

GGT(U/L)

(10-67)

TB(μmol/L)

(5.1-22.2)

DB(μmol/L)

(0-8.6)

ALP(U/L)

(30-120)

Symptoms

2012-4-12

ZOL infusion (5 mg)

33

15

45

9.8

2.6

77

Fever 38.7 °C, myalgia, arthralgia

2012-4-15

glucurolactone (100 mg 3/d), polyene )

254

73

135

6.3

2.4

 

2014-4-18

phosphatidylcholine (456 mg 3/d

126

43

112

7.7

2.5

118

2012-4-21

 

66

40

-

11.2

4.3

 

2013-5-7

ZOL infusion (5 mg), glucurolactone (100 mg 3/d)

28

18

30

9.6

2.9

44

Fever 38.0 °C, arthralgia

2013-5-10

 

70

40

46

4.6

1.6

-

 

2013-5-13

48

22

43

6.0

2.1

58

 

2014-6-22

ZOL infusion (5 mg), glucurolactone (100 mg 3/d)

24

20

27

7.2

2.4

51

No fever or pain

2014-6-25

 

31

28

33

5.9

1.6

55

 
  1. ALT alanine aminotransferase, AST aspartate aminotransferase, GGT gamma-glutamyltransferase, TB total bilirubin, DB direct bilirubin, ALP alkaline phosphatase