Table 2 Studied variables and genotype distribution according to the nocturnal dipping
Variable | Dippers (n = 50) | Non-dippers (n = 105) | p value |
|---|---|---|---|
Age (years) | 62.8 ± 12.0 | 63.5 ± 11.1 | NS |
Gender (Male/Female) | 22/28 | 44/61 | NS |
Duration of hypertension (years) | 14.7 ± 11.1 | 16.6 ± 9.6 | NS |
BMI (kg/m2) | 28.3 ± 4.8 | 29.0 ± 5.0 | NS |
Smoker, n (%) | 6 (12.0) | 10 (9.5) | NS |
History of stroke, n (%) | 12 (24.0) | 23 (21.9) | NS |
History of myocardial infarction, n (%) | 1 (2.0) | 6 (5.7) | NS |
LVH, n (%) | 16 (34.0) | 36 (34.6) | NS |
Microalbuminuria, n (%) | 26 (52.0) | 64 (60.9) | NS |
Drugs | |||
Hypolipemiant, n (%) | 18 (36.0) | 53 (50.5) | NS |
Aspirin, n (%) | 15 (30.0) | 44 (41.9) | NS |
Diuretic, n (%) | 44 (88.0) | 85 (80.9) | NS |
ACE inhibitor, n (%) | 31 (62.0) | 72 (68.6) | NS |
Angiotensin II receptor antagonist, n (%) | 7 (14.0) | 15 (14.3) | NS |
Calcium channel blocker, n (%) | 24 (48.0) | 41 (39.0) | NS |
Beta-blocker, n (%) | 11 (22.0) | 35 (33.3) | NS |
Blood pressure levels | |||
24-h SBP (mmHg) | 134.6 ± 19.0 | 135.6 ± 16.6 | NS |
24-h DBP (mmHg) | 81.7 ± 9.9 | 81.7 ± 11.6 | NS |
Daytime SBP (mmHg) | 140.1 ± 19.6 | 136.1 ± 16.6 | NS |
Daytime DBP (mmHg) | 85.8 ± 10.4 | 82.7 ± 12.3 | NS |
Nighttime SBP (mmHg) | 118.7 ± 16.7 | 133.9 ± 18.4 | <0.001 |
Nighttime DBP (mmHg) | 69.3 ± 9.2 | 78.0 ± 11.9 | <0.001 |
SBP dipping (%) | 15.1 ± 4.6 | 1.4 ± 5.6 | <0.001 |
SBP dipping (%) | 19.0 ± 5.7 | 5.6 ± 7.0 | <0.001 |
Echocardiographic profile | |||
Septal thickness (mm) | 10.1 ± 1.6 | 10.1 ± 1.8 | NS |
Wall thickness (mm) | 9.8 ± 1.5 | 9.9 ± 3.4 | NS |
LV mass (g) | 200.0 ± 64.4 | 204.8 ± 91.3 | NS |
LV mass index (g/m2) | 112.8 ± 31.8 | 115.6 ± 53.1 | NS |
Biochemical profile | |||
Fasting glycemia (mg/dL) | 95.6 ± 18.9 | 97.1 ± 13.8 | NS |
HDL-cholesterol (mg/dL) | 56.7 ± 15.2 | 56.8 ± 16.6 | NS |
LDL-cholesterol (mg/dL) | 110.8 ± 22.7 | 109.2 ± 31.6 | NS |
Total cholesterol (mg/dL) | 193.6 ± 28.4 | 184.3 ± 38.6 | NS |
Triglycerides (mg/dL) | 138.8 ± 71.6 | 130.9 ± 81.4 | NS |
Creatinine (mg/dL) | 1.2 ± 0.3 | 1.3 ± 1.1 | NS |
Microalbuminuria (µg/min) | 38.2 ± 59.1 | 31.6 ± 39.7 | NS |
Genotype | |||
II, n (%) | 8 (16.0) | 16 (15.2) | NS |
ID, n (%) | 25 (50.0) | 62 (59.0) | |
DD, n (%) | 17 (34.0) | 27 (25.7) | |
Genotype combination | |||
II, n (%) | 8 (16) | 16 (15.3) | NS |
D_, n (%) | 42 (84) | 89 (84.7) | |