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TableĀ 2 PALB2 missense variants and prediction of pathogenicity

From: PALB2 mutations in breast cancer patients from a multi-ethnic region in northwest China

Exon Nucleotide change Protein change Mutation cases SIFT score Polyphen score
10 c.3035C>T p.T1012I 1 0 0.997
7 c.2720A>G p.E907G 1 0.02 0.983
4 c.1273G>A p.V425M 1 0.01 0.002
4 c.925A>G p.I309V 3 1 0
4 c.691A>G p.K231E 1 0.04 0.023
10 c.3054G>C p.E1018D 2 0.03 0.95
12 c.3306C>G p.S1102R 1 0.01 0.119
7 c.2699C>T p.A900V 1 0.02 0.024
2 c.64G>A p.A22T 1 0 0.98