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Table 1 Characteristics of the recent and past groups of patients with intracranial germ cell tumors

From: An update on the clinical diagnostic value of β-hCG and αFP for intracranial germ cell tumors

Items

 

Past group (n = 32)

Recent group (n = 26)

  

Patients demographics

 Sex ratio (male:female)

 

17:15 (1.1:1)

17:9 (1.9:1)

  

 Age at diagnosis (years), mean ± SD (range)*

 

19 ± 6.9 (9–41)

12.7 ± 4.3 (6–24)

  

Tumor characteristics

Pathological classification, n (%)

Germinoma

31 (90.6)

17 (65.4)

  
 

NGGCTs

0 (0)

2 (7.7)

  
 

Mixed type

1 (9.4)

7 (26.9)

  

Tumor location, n (%)a

Pineal

1 (3.1)

4 (15.3)

  
 

Sellar

19 (59.4)

10 (38.5)

  
 

Basal Ganglia

4 (12.5)

6 (23.1)

  
 

Mixed type

8 (25)

6 (23.1)

  

M staging (cases)

M0 (22/16)

M1 (4/1)

M2 (4/9)

M3 (2/0)

M4 (0/0)

Method of confirmation

 CSF cytology, n (%)

Total cases

14 (43.8)

26 (100)

  
 

Positive

9 (64.3)

1 (3.8)

  

Surgical resection

 

Germinoma

NGGCTs

Mixed type

Total

 

Biopsy

8/16

0/0

0/2

8/18

 

PR

7/0

0/0

1/1

8/1

 

STR

7/1

0/2

0/1

7/4

 

GTR

0/0

0/0

0/2

0/2

 

No surgery

9/1

0/0

0/0

9/1

History of radiography (cases)

 

0/1

0/1

0/1

0/3

  1. NGGCTs non-geminomatous germ cell tumors, CSF cerebrospinal fluid; PR partial resection, STR subtotal resection, GTR total resection, M staging: metastasis staging)
  2. * P < 0.05 recent vs. the past groups
  3. aBoth groups showed that the sellar region was the most common site, with a higher proportion in females; in addition to the classic bifocal tumors (sellar and pineal), there were other types of bifocal tumors (basal ganglia and sellar region) as well as triple lesions (pineal, sellar, and basal ganglia)