From: Vitamin D and airway infections: a European perspective
Author (ref.) | Publication year | N (total) | Age (years) | 25OHD (nmol/l) | 25OHD (nmol/l) | Mean vitamin D dose (IU) | Duration | Endpoint | ||
---|---|---|---|---|---|---|---|---|---|---|
Initial | In-study | |||||||||
Vit D | Placebo | Vit D | Placebo | |||||||
Aloia [54] | 2007 | 208 | 60.6 | 46.9 | 43 | 86.9 | 43 | 800/2000 daily | 3Â years | Influenza |
Li-Ng [55] | 2009 | 148 | 58.7 | 58.7 | 63 | 88.5 | 60.9 | 2000 daily | 3Â months | URTI |
Laaksi [52] | 2010 | 164 | Young men | 78.7 | 74.4 | 72 | 51 | 400 daily | 6Â months | Acute RTI |
Manaseki-Holland [56] | 2010 | 453 | 1.2 | ND | ND | ND | ND | 100,000 (single dose) | 3Â weeks | Pneumonia |
Urashima [57] | 2010 | 334 | 10.2 | ND | ND | ND | ND | 1200 daily | 4Â months | Influenza A |
Majak [58] | 2011 | 48 | 11.5 | 64.3 | 88 | 94 | 80 | 500 daily | 6Â months | Acute RTI |
Bergman [59] | 2012 | 124 | 53.1 | 51.5 | 46.9 | 117.4 | 44 | 4000 daily | 12Â months | RTI |
Camargo [60] | 2012 | 244 | 19.9 | 17.5 | 17 | 47.3 | 18 | 300 daily | 7Â weeks | Acute RTI |
Jorde [61] | 2012 | 569 | 63 | ND | ND | ND | ND | 3344c | 12Â months | Influenza-like |
Manaseki-Holland [62] | 2012 | 3046 | 0.8 | ND | ND | a | b | 100,000 quarterly | 18Â months | Pneumonia |
Murdoch [63] | 2012 | 322 | 47.5 | 75.5 | 70 | 122.5 | 55 | 100,000 monthlyd | 18Â months | URTI |
Rees [64] | 2013 | 759 | 58.1 | 62 | 63.1 | ND | ND | 1000 daily | 3–5 years | URTI |
Urashima [65] | 2014 | 247 | Students | ND | ND | ND | ND | 2000 daily | 2Â months | Influenza A |
Goodall [66] | 2014 | 471 | 19 | ND | ND | ND | ND | 10,000 weekly | 2Â months | URTI |
Simpson [67] | 2015 | 34 | Healthy adults | 60.5 | 76.4 | 107 | 46 | 20,000 weekly | 17Â weeks | RTI |
Martineau [68] | 2015 | 250 | 47.9 | 49.8 | 49.4 | 69.4 | 46.5 | 120,000 bimonthly | 1Â year | Acute RTI |