Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of non-small cell lung cancer in Andhra Pradesh region of South India

Table 10 Association of glutathione peroxidase activity in relation to CYP1A1 and GST gene polymorphisms in NSCLC patients and healthy controls

Gene	Genotype	Lung cancer patients (GPx levels)		p value	Controls (GPx levels)		p value	Total p value
Gene	Genotype	n	Mean ± SE	p value	n	Mean ± SE	p value	Total p value
CYP1A1 m1	T/T	121	47.51 ± 4.52		138	55.44 ± 0.60		<0.01*
	T/C	89	45.77 ± 2.45	0.01*	98	55.15 ± 0.69	0.74	<0.01*
	C/C	28	43.42 ± 2.02	<0.01*	14	51.42 ± 1.74	0.79	0.06
CYP1A1 m2	A/A	71	48.18 ± 6.45		196	59.35 ± 0.33		<0.01*
	A/G	156	44.02 ± 1.75	<0.01*	34	55.26 ± 0.65	0.17	<0.02*
	G/G	11	45.94 ± 2.93	0.01*	20	54.67 ± 0.91	0.53	<0.01*
GSTM1	+/+	174	46.22 ± 1.74		187	57.69 ± 0.36		<0.01*
	–/–	64	40.87 ± 2.69	0.33	63	54.41 ± 0.84	0.21	<0.01*
GSTT1	+/+	192	46.66 ± 1.53		224	55.50 ± 0.47		<0.001*
	–/–	46	36.95 ± 3.95	0.05*	26	51.69 ± 1.12	0.07	<0.001*

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