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Table 12 Urinary 8-OHdG levels (ng/mg creatinine) in relation to CYP1A1 and GST gene polymorphisms in NSCLC patients and healthy controls

From: Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of non-small cell lung cancer in Andhra Pradesh region of South India

Gene Genotype Lung cancer patients (8-OhdG levels) p value Controls (8-OhdG levels) p value Total p value
n Mean ± SE n Mean ± SE
CYP1A1 m1 T/T 64 6.03 ± 0.09   57 4.22 ± 0.10   0.71
  T/C 45 6.08 ± 0.12 0.41 37 4.44 ± 0.11 0.44 0.25
  C/C 16 6.11 ± 0.23 0.18 6 4.50 ± 0.19 0.27 0.13
CYP1A1 m2 A/A 41 5.91 ± 0.21   79 4.28 ± 0.17   0.42
  A/G 78 6.03 ± 0.09 0.007* 17 4.37 ± 0.17 0.47 0.58
  G/G 6 6.13 ± 0.13 0.04* 4 4.75 ± 0.19 0.45 0.67#
GSTM1 +/+ 102 5.97 ± 0.78   71 4.26 ± 0.85   0.39
  –/– 23 6.43 ± 0.16 0.60 29 4.61 ± 0.10 0.28 0.07
GSTT1 +/+ 101 5.88 ± 0.69   88 4.23 ± 0.64   0.16
  –/– 24 6.82 ± 0.17 0.02* 12 5.35 ± 0.10 0.63 0.04*
  1. p < 0.05
  2. #yates corrected Chi square