Table 12 Urinary 8-OHdG levels (ng/mg creatinine) in relation to CYP1A1 and GST gene polymorphisms in NSCLC patients and healthy controls
Gene | Genotype | Lung cancer patients (8-OhdG levels) | p value | Controls (8-OhdG levels) | p value | Total p value | ||
|---|---|---|---|---|---|---|---|---|
n | Mean ± SE | n | Mean ± SE | |||||
CYP1A1 m1 | T/T | 64 | 6.03 ± 0.09 |  | 57 | 4.22 ± 0.10 |  | 0.71 |
|  | T/C | 45 | 6.08 ± 0.12 | 0.41 | 37 | 4.44 ± 0.11 | 0.44 | 0.25 |
|  | C/C | 16 | 6.11 ± 0.23 | 0.18 | 6 | 4.50 ± 0.19 | 0.27 | 0.13 |
CYP1A1 m2 | A/A | 41 | 5.91 ± 0.21 |  | 79 | 4.28 ± 0.17 |  | 0.42 |
|  | A/G | 78 | 6.03 ± 0.09 | 0.007* | 17 | 4.37 ± 0.17 | 0.47 | 0.58 |
|  | G/G | 6 | 6.13 ± 0.13 | 0.04* | 4 | 4.75 ± 0.19 | 0.45 | 0.67# |
GSTM1 | +/+ | 102 | 5.97 ± 0.78 |  | 71 | 4.26 ± 0.85 |  | 0.39 |
|  | –/– | 23 | 6.43 ± 0.16 | 0.60 | 29 | 4.61 ± 0.10 | 0.28 | 0.07 |
GSTT1 | +/+ | 101 | 5.88 ± 0.69 |  | 88 | 4.23 ± 0.64 |  | 0.16 |
|  | –/– | 24 | 6.82 ± 0.17 | 0.02* | 12 | 5.35 ± 0.10 | 0.63 | 0.04* |