Skip to main content

Table 6 Risk of NSCLC associated with CYP1A1 m1, m2, GSTM1, GSTT1 genotypes stratified by smoking exposure

From: Association of CYP1A1, GSTM1 and GSTT1 gene polymorphisms with risk of non-small cell lung cancer in Andhra Pradesh region of South India

Variables smoking status Cases/ controls non-smokers 98/175 OR (95 % CI) non-smokers p Cases/ controls smokers 148/75 OR (95 % CI) smokers p value
CYP1A1m1 (T/T) 49/115 0.52 (0.31, 0.86) 0.01 63/58 0.21 (0.11, 0.40) <0.001
CYP1A1m1 (T/C) 40/48 1.82 (1.08, 3.07) 0.02* 70/15 3.59 (1.87, 6.88) <0.001 *
CYP1A1m1 (C/C) 9/12 1.37 (0.56, 3.38) 0.48 15/2 4.11 (0.91,18.5) 0.04*,#
CYP1A1m2 (A/A) 33/142 0.11 (0.06, 0.20) 0.001 40/54 0.14 (0.07, 0.26) <0.001
CYP1A1m2 (A/G) 56/17 12.39 (6.53, 23.51) 0.001* 87/17 4.86 (2.58, 9.15) <0.001*
CYP1A1m2 (G/G) 9/16 1.05 (0.42, 2.36) 0.99 21/4 2.93 (0.96, 8.88) 0.04*,#
GSTM1 (+/+) 76/133 1.09 (0.60, 1.96) 0.77 106/54 0.98 (0.52, 1.82) 0.95
GSTM1 (−/−) 22/42 0.92 (0.51, 1.65) 0.77 42/21 1.01 (0.54, 1.89) 0.95
GSTT1 (+/+) 89/158 1.06 (0.45, 2.48) 0.88 111/66 0.40 (0.18, 0.90) 0.02
GSTT1 (-/-) 9/17 0.93 (0.40, 2.19) 0.88 37/9 2.44 (1.11, 5.38) 0.02*
  1. p < 0.05
  2. #Yates corrected Chi square