Table 6 Risk of NSCLC associated with CYP1A1 m1, m2, GSTM1, GSTT1 genotypes stratified by smoking exposure
Variables smoking status | Cases/ controls non-smokers 98/175 | OR (95Â % CI) non-smokers | p | Cases/ controls smokers 148/75 | OR (95Â % CI) smokers | p value |
|---|---|---|---|---|---|---|
CYP1A1m1 (T/T) | 49/115 | 0.52 (0.31, 0.86) | 0.01 | 63/58 | 0.21 (0.11, 0.40) | <0.001 |
CYP1A1m1 (T/C) | 40/48 | 1.82 (1.08, 3.07) | 0.02* | 70/15 | 3.59 (1.87, 6.88) | <0.001 * |
CYP1A1m1 (C/C) | 9/12 | 1.37 (0.56, 3.38) | 0.48 | 15/2 | 4.11 (0.91,18.5) | 0.04*,# |
CYP1A1m2 (A/A) | 33/142 | 0.11 (0.06, 0.20) | 0.001 | 40/54 | 0.14 (0.07, 0.26) | <0.001 |
CYP1A1m2 (A/G) | 56/17 | 12.39 (6.53, 23.51) | 0.001* | 87/17 | 4.86 (2.58, 9.15) | <0.001* |
CYP1A1m2 (G/G) | 9/16 | 1.05 (0.42, 2.36) | 0.99 | 21/4 | 2.93 (0.96, 8.88) | 0.04*,# |
GSTM1 (+/+) | 76/133 | 1.09 (0.60, 1.96) | 0.77 | 106/54 | 0.98 (0.52, 1.82) | 0.95 |
GSTM1 (−/−) | 22/42 | 0.92 (0.51, 1.65) | 0.77 | 42/21 | 1.01 (0.54, 1.89) | 0.95 |
GSTT1 (+/+) | 89/158 | 1.06 (0.45, 2.48) | 0.88 | 111/66 | 0.40 (0.18, 0.90) | 0.02 |
GSTT1 (-/-) | 9/17 | 0.93 (0.40, 2.19) | 0.88 | 37/9 | 2.44 (1.11, 5.38) | 0.02* |