Fig. 3From: HDAC inhibition activates the apoptosome via Apaf1 upregulation in hepatocellular carcinomaApoptosis after siRNA transfection against HDAC1–3. Apoptosis measured by flow cytometry using annexin V staining in HLE a and HLF b is increased in both cell lines. Caspase-9 activity in the HCC cell lines c HLE and d HLF normalized to cell count after 48 h showed a significant increase in caspase-9 activity in both cell lines compared with controls. Values are mean ± SEM, n = 3. **p < 0.01, *p = <0.05, ANOVA plus Dunnett’s posttestBack to article page