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Table 2 Factors associated with 30-day readmission in all, younger, and older patients

From: Unplanned readmissions in younger and older adult patients: the role of healthcare-related adverse events

Possible factors (reference) Multivariate analyses in all agesb Multivariate analyses in younger patients (<65 years)b Multivariate analyses in older patients (≥65 years)b
Total study population AE groupc Total study population AE groupc Total study population AE groupc
N = 940 N = 333 N = 485 N = 157 N = 455 N = 176
HR (95 % CI) p value HR (95 % CI) p value HR (95 % CI) p value HR (95 % CI) p value HR (95 % CI) p value HR (95 % CI) p value
Age, in yearsa 1.12 (0.78–1.62) 0.53 0.97 (0.54–1.73) 0.91 1.03 (1.011.05) 0.02 1.01 (0.97–1.05) 0.61 0.98 (0.95–1.02) 0.37 1.02 (0.96–1.08) 0.51
Sex (female) 0.78 (0.55–1.11) 0.17 0.63 (0.35–1.11) 0.11 0.80 (0.49–1.31) 0.37 0.70 (0.31–1.58) 0.39 0.77 (0.46–1.27) 0.30 0.48 (0.20–1.15) 0.10
CCI (0–2) 1.45 (0.99–2.12) 0.06 1.31 (0.74–2.33) 0.35 1.59 (0.89–2.83) 0.12 1.84 (0.81–4.19) 0.15 1.16 (0.68–1.96) 0.59 0.90 (0.39–2.08) 0.81
Number of medications used (0–5)
 5–10 0.79 (0.53–1.19) 0.27 0.89 (0.47–1.68) 0.72 0.84 (0.45–1.56) 0.58 0.86 (0.35–2.14) 0.75 0.67 (0.39–1.18) 0.17 0.88 (0.35–2.20) 0.78
 10–15 0.66 (0.34–1.25) 0.20 0.62 (0.25–1.54) 0.30 1.34 (0.50–3.62) 0.56 0.57 (0.13–2.47) 0.46 0.40 (0.170.95) 0.04 0.54 (0.16–1.83) 0.32
 >15 0.63 (0.20–1.97) 0.42 0.87 (0.22–3.50) 0.85 1.35 (0.29–6.20) 0.70 1.28 (0.19–8.63) 0.80 0.22 (0.03–1.76) 0.15 0.48 (0.05–4.56) 0.52
ADL dependency 2.43 (1.105.35) 0.03 7.05 (1.6130.9) 0.01 1.76 (0.25–12.4) 0.57 1.40 (0.12–16.9) 0.78 3.19 (1.278.01) 0.01 10.0 (1.6262.3) 0.01
Cognitive impairment 0.54 (0.25–1.17) 0.12 0.26 (0.04–1.57) 0.14 0.74 (0.14–3.91) 0.72 0.45 (0.18–1.12) 0.09 0.24 (0.03–1.84) 0.17
Living situation (home) 0.67 (0.29–1.56) 0.36 0.24 (0.04–1.40) 0.11 0.41 (0.03–5.45) 0.50 0.91 (0.36–2.33) 0.85 0.25 (0.04–1.82) 0.17
AE as reason for the index admission 1.20 (0.83–1.75) 0.33 NA NA 1.12 (0.65–1.95) 0.68 NA NA 1.12 (0.66–1.91) 0.68 NA NA
Length of stay (linear) 1.01 (0.99–1.02) 0.45 0.99 (0.96–1.03) 0.67 1.02 (0.99–1.04) 0.21 1.0 (0.94–1.06) 0.93 0.99 (0.96–1.02) 0.53 0.99 (0.95–1.03) 0.65
Season of discharge (summer)
 Spring 0.83 (0.52–1.33) 0.44 0.71 (0.32–1.55) 0.39 0.74 (0.37–1.48) 0.39 0.65 (0.21–2.03) 0.46 0.93 (0.48–1.81) 0.84 0.92 (0.29–2.91) 0.89
 Autumn 0.60 (0.36–1.01) 0.05 0.50 (0.22–1.14) 0.10 1.03 (0.52–2.02) 0.94 0.62 (0.20–1.95) 0.41 0.33 (0.140.77) 0.01 0.42 (0.12–1.49) 0.18
 Winter 1.10 (0.69–1.76) 0.69 0.84 (0.40–1.77) 0.66 1.12 (0.57–2.19) 0.75 0.86 (0.30–2.46) 0.78 1.01 (0.51–1.98) 0.98 0.82 (0.27–2.51) 0.83
Day of discharge (weekday) 1.10 (0.71–1.70) 0.66 1.46 (0.77–2.76) 0.24 1.27 (0.71–2.27) 0.42 1.26 (0.52–3.06) 0.61 0.93 (0.47–1.85) 0.85 1.59 (0.62–4.07) 0.33
  1. Numbers in italic show significant differences
  2. HR hazard ratio, CI confidence interval, CCI Charlson comorbidity index, ADL activity in daily living, AE adverse event, NA not applicable
  3. aIn the multivariate analyses of all ages, age was included as binominal covariate (≤65 and >65 years), in the multivariate analyses in younger and older patients, age was included as linear covariate
  4. bIADL was omitted out of the equation due to collinearity with ADL. Because of insufficient cases, admission reasons could not be included in the analyses. In the AE group of younger patients, cognition and living situation could not be included in the analyses due to insufficient cases
  5. cLogistic regression analysis performed in the subgroup of patients with an index admission because of an AE