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Table 5 Value of serological analysis of c-reactive protein (CRP) and erythrocyte sedimentation rate (ESR)

From: Prosthetic joint infection development of an evidence-based diagnostic algorithm

Author Year LoE CoR (n = x) Sensitivity Specificity Positive predictive value Negative predictive value LR for a positive result LR for a negative result
Bottner et al. 2007 I I 78       
 CRP (1.5 mg/dl)      0.95 (0.86–1.0) 0.91 (0.94–0.99) 0.8 (0.64–0.96) 0.98 (0.94–1.0) 10.86 (5.3–73.07) 0.05 (0.0–0.17)
 ESR (32 mm/h)      0.81 (0.64–0.98) 0.89 (0.82–0.97) 0.74 (0.56–0.92) 0.93 (0.8–1.0) 7.69 (3.47–38.2) 0.21 (0.02–0.44)
Savarino et al. 2004 I I 26       
 ESR (50 mm/h)      0.6 (0.3–0.9) 0.94 (0.82–1.0) 0.86 (0.71–1.0) 0.79 (0.61–0.97) 9.6 (1.64–16.1) 0.43 (0.09–0.86)
 CRP (2 mg/dl)      0.38 (0.14–0.61) 0.7 (0.42–0.98) 0.67 (0.36–0.97) 0.42 (0.18–0.65) 1.25 (0.24–38.34) 0.89 (0.39–2.07)
Kamme et al. 1980 I I 63       
 ESR(30 mm/h)      0.89 (0.8–0.99) 0.72 (0.54–0.9) 0.83 (0.71–0.94) 0.82 (0.66–0.98) 3.2 (1.75–9.54) 0.15 (0.01–0.37)
Greidanus et al. 2007 I I 151       
 ESR (30 mm/h)      0.82 (0.71–0.93) 0.88 (0.81–0.94) 0.74 (0.62–0.86) 0.92 (0.87–0.97) 6.7 (3.84–15.52) 0.2 (0.07–0.36)
 CRP (1.0 mg/dl)      0.93 (0.86–1.0) 0.83 (0.76–0.9) 0.7 (0.58–0.82) 0.97 (0.93–1.0) 5.5 (3.57–10.23 0.08 (0.01–0.18)
Della Valle et al. 2007 I I 94       
 ESR (30 mm/h)      0.9 (0.81–0.99) 0.66 (0.53–0.79) 0.67 (0.55–0.8) 0.9 (0.8–0.99) 2.66 (1.74–4.68) 0.15 (0.01–0.35)
 CRP (1 mg/dl)      0.95 (0.89–1.00) 0.75 (0.64–0.87) 0.75 (0.63–0.87) 0.95 (0.89–1.0) 3.88 (2.45–7.86) 0.06 (0.02–0.18)
Schinsky et al. 2008 I I 201       
 ESR (30 mm/h)      0.96 (0.91–1.0) 0.39 (0.31–0.47) 0.37 (0.29–0.45) 0.97 (0.92–1.0) 1.58 (1.33–1.91) 0.09 (0.0–0.28)
 CRP (1 mg/dl)      0.95 (0.89–1.0) 0.71 (0.94–1.0) 0.55 (0.45–0.65) 0.97 (0.94–1.0) 3.29 (2.45–4.69) 0.08 (0.0–0.18)
Fink et al. 2007 I I 145       
 CRP (1.35 mg/dl)      0.73 (0.59–0.86) 0.81 (0.73–0.88) 0.59 (0.45–0.73) 0.89 (0.82–0.95) 3.81 (2.21–7.48) 0.34 (0.15–0.56)
Bottner et al. 2007 I I 78 0.95 0.87 0.74 0.98 n.p. n.p.
 IL-6 (>12 pg/ml)      0.43 0.94 0.75 0.85 n.p. n.p.
 TNF-a (>40 nl/ml)      0.33 0.98 0.87 0.8 n.p. n.p.
 PCT (>0.3 ng/ml)           
Di Cesare et al. 2005 III III 58       
 Il-6 (>10 pg/ml)     1 0.95 (0.89–1.0) 0.88 (0.73–1.0) 1 21.5 (9.14–60.85) 0