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Table 6 Value of joint aspiration in the diagnosis of infected total knee arthroplasty

From: Prosthetic joint infection development of an evidence-based diagnostic algorithm

Author Year LoE CoR (n = x) Sensitivity Specificity Positive predictive value Negative predictive value LR for a positive result LR for a negative result
Della Valle et al. 2007 I I 94       
 Aspiration culture      0.8 0.93 0.94 0.84 n.p. n.p.
 WBC (3.0 × 103)      0.98 (0.93–1.9) 1 1 0.98 (0.94–1.0) X 0.02
 Neutrophile-%      0.98 (0.93–1.0) 0.85 (0.75–0.95) 0.83 (0.73–0.94) 0.98 (0.94–1.0) 6.46 (3.75–18.75) 0.03 (0–0.1)
Fink et al. 2007 I I 145       
 Aspiration culture      0.73 (0.59–0.86) 0.95 (0.91–0.99) 0.85 (0.73–0.97) 0.9 (0.85–0.96) 15.23 (6.64–125.4) 0.29 (0.14–0.45)
Ghanem et al. 2008 I I 429       
 WBC (3.0 × 103)      0.91 (0.86–0.95) 0.88 (0.84–0.92) 0.82 (0.76–0.88) 0.94 (0.91–0.97) 7.59 (5.45–11.81) 0.11 (0.05–0.16)
 Neutorphile (64%)      0.95 (0.92–0.98) 0.95 (0.92–0.97) 0.92 (0.87–0.96) 0.97 (0.95–0.99) 18.19 (11.62–38.43) 0.05 (0.02–0.09)
Trampuz et al. 2007 I I        
 WBC (1.7 × 103)      0.94 (0.86–1.0) 0.88 (0.81–0.94) 0.73 (0.60–0.86) 0.98 (0.95–1.0) 7.76 (4.65–17.92) 0.07 (0.0–0.17)
 Neutrophi (65%)      0.97 (0.91–1.0) 0.98 (0.95–1.0) 0.94 (0.87–1.0) 0.99 (0.97–1.0) 48.04 (19.07–136.76) 0.03 (0.0–0.09)
Zmistowski et al. 2012 I I 150       
 WBC (3.0 × 103)      0.93 (0.87–0.99) 0.94 (0.88–0.99) 0.93 (0.87–0.99 0.94(0.88–0.99) 14.35 (7.28–99) 0.07 (0.01–0.14)
 Neutrophile (75%)      0.93 (0.87–0.99) 0.83 (0.75–0.91) 0.84 (0.76–0.92) 0.93 (0.87–0.99) 5.52(3.46–11.62) 0.08 (0.01–0.17)