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Table 8 Value of synovial biopsy

From: Prosthetic joint infection development of an evidence-based diagnostic algorithm

Author Year LoE CoR (n = x) Sensitivity Specifity Positive predictive value Negative predictive value LR for a positive result LR for a negative result
Banit et al. 2002 I I        
 Frozen section (Hip)     63 0.45 (0.16–0.75) 0.92 (0.85–1.0) 0.56 (0.23–0.88) 0.89 (0.81–0.97) 5.91 (1.07–166.5) 0.59 (0.25–0.99)
 Frozen section (knee)     55 1 0.96 (0.9–1.0) 0.82 (0.59–1.0) 1 23.00 (9.76–64.7) 0
 (Knee + hip.shoulder)     121 0.67 (0.48–0.86) 0.95 (0.91–1.0) 0.8 (0.62–0.98) 0.91 (0.86–0.97) 14.67 (5.37–442) 0.35 (0.15–0.57)
Borrego et al. 2007 I I        
 Frozen sectio (Hip)     83 0.5 (0.15–0.85) 1 1 0.95 (0.9–1.0) X 0.5 (0.15–0.85)
 Frozen section (knee)     63 0.67 (0.48–0.86) 0.9 (0.8–0.99) 0.8 (0.62–0.98) 0.81 (0.7–0.93) 6.5 (2.42–116.4) 0.37 (0.15–0.65)
Schinsky et al. 2008 I I 201       
 Frozen section      0.73 (0.61–0.84) 0.94 (0.9–0.98) 0.82 (0.71–0.92) 0.9 (0.85–0.95) 11.8 (6.06–37.34) 0.29 (0.16–0.43)
Fink et al. 2008 I I 145       
 Fixed section (knee)      1 0.98 (0.95–1.0) 0.95 (0.89–1.0) 1 52.5 (22.13–140.88) X
 Tissue culture (knee)      0.78 (0.65–0.9) 0.98 (0.95–1.0) 0.94 (0.86–1.0) 0.92 (0.87–0.97) 40.69 (14.28–127.41) 0.23 (0.09–0.37)
 Both      0.78 (0.65–0.9) 0.98 (0.95–1.0) 0.94 (0.86–1.0) 0.92 (0.87–0.97) 40.69 (14.28–127.41) 0.23 (0.09–0.37)
Della Valle et al. 2007 I I 94       
 Forzen section      0.88 (0.78–0.98) 0.96 (0.91–1.0) 0.95 (0.88–1.0) 0.91 (0.84–0.99) 23.27 (8.74–72.1) 0.13 (0.02–0.24)
Fink et al. 2013 I I 100       
 Fixed section (hip)      0.62 (0.48–0.76) 1 1 0.76 (0.67–0.86) X 0.38 (0.24–0.52)
 Tissue culture (hip)      0.73 (0.6–0.86) 0.98 (0.95–1.0) 0.97 (0.91–1.0) 0.82 (0.73–0.91) 40.33 (11.29–50.36) 0.27 (0.14–0.42)
 Both      0.82 (0.71–0.93) 0.98 (0.95–1.0) 0.97 (0.92–1.0) 0.87 (0.06–0.31) 45.22 (13.28–54.52) 0.18 (0.06–0.31)