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Fig. 4 | European Journal of Medical Research

Fig. 4

From: Microneedle physical contact as a therapeutic for abnormal scars

Fig. 4

Microneedle patch application on a hypertrophic scar on the dorsal region. a Gross appearance of hypertrophic scar before treatment. b Application of the microneedle patches on the caudal half of the scar. c Hypertrophic scar following treatment (inset indicating control (c) and microneedle-treated (M) portions). Corresponding histology indicating a reduction of inflammatory signs compared to the untreated control. df H&E staining of the untreated control. Magnifications using ×4, ×10, and ×20, respectively. gi Masson–Goldner–Trichrome staining of the untreated control. Magnifications using ×4, ×10, and ×20, respectively. jl H&E staining of the treated scar. Magnifications using ×4, ×10, and ×20 respectively. mo Masson–Goldner–Trichrome staining of the treated scar. Magnifications using ×4, ×10, and ×20, respectively. Black arrows indicate leukocyte infiltration. White arrows indicate disrupted connective tissue. v vessels

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