Fig. 4From: Microneedle physical contact as a therapeutic for abnormal scarsMicroneedle patch application on a hypertrophic scar on the dorsal region. a Gross appearance of hypertrophic scar before treatment. b Application of the microneedle patches on the caudal half of the scar. c Hypertrophic scar following treatment (inset indicating control (c) and microneedle-treated (M) portions). Corresponding histology indicating a reduction of inflammatory signs compared to the untreated control. d–f H&E staining of the untreated control. Magnifications using ×4, ×10, and ×20, respectively. g–i Masson–Goldner–Trichrome staining of the untreated control. Magnifications using ×4, ×10, and ×20, respectively. j–l H&E staining of the treated scar. Magnifications using ×4, ×10, and ×20 respectively. m–o Masson–Goldner–Trichrome staining of the treated scar. Magnifications using ×4, ×10, and ×20, respectively. Black arrows indicate leukocyte infiltration. White arrows indicate disrupted connective tissue. v vesselsBack to article page