Skip to main content

Table 1 GWAS on the genetic mechanism of chronic hepatitis B

From: Advances in the genome-wide association study of chronic hepatitis B susceptibility in Asian population

 

Ethnicity

SNP

Chromosome (locus)

Odds ratio

P value (combined stage)

References

1

Japanese

Korean

Indonesian

rs9277535

6 (HLA-DPB1)

1.39–1.89

3.0 × 10−54

−3.0 × 10−12

[10,11,12]

[18, 19]

2

Japanese

East Asian

Korean

rs3077

6 (HLA-DPA1)

1.78–1.89

2.0 × 10−61

−2.0 × 10−38

[10,11,12]

[14, 17, 18]

3

Japanese

Korean

rs2856718

6 (TRNAI25)

1.56–1.60

4.0 × 10−37

2.0 × 10−24

[11, 12]

[17, 18]

4

Japanese

Korean

Chinese

rs7453920

6 (HLA-DQB2)

1.81–2.00

5.0 × 10−37

~7.0 × 10−26

[11, 12, 16]

[17, 18]

5

Korean

rs1419881

6 (TCF19)

1.37

1.0 × 10−18

[12, 18]

6

Korean

rs652888

6 (EHMT2)

1.38

7.0 × 10−13

[12, 18]

7

Korean

rs9394021

6 (VARS2)

0.78

1.7 × 10−6

[13]

8

Korean

rs2517459

6 (VARS2-SFTA2)

0.56

1.7 × 10−10

[13]

9

East Asian

rs9277542

6 (HLA-DPB1)

1.64

2.0 × 10−21

[14]

10

Chinese

rs11866328

16 (GRIN2A)

1.68

2.0 × 10−8

[15]

11

Chinese

rs4821116

22 (UBE2L3)

1.22

2.0 × 10−12

[16]

12

Chinese

rs3130542

6 (TRNAI25)

1.33

9.0 × 10−14

[16, 18]

13

Chinese

rs352140

3 (TLR9)

0.70

8.8 × 10−3

[17]

14

Chinese

rs16944

2 (IL1B)

0.67

1.6 × 10−2

[17]

15

Chinese

rs3212227

5 (IL12B)

1.38

2.1 × 10−2

[17]

16

Chinese

rs3799488

13 (IFNGR1)

1.48

4.8 × 10−3

[17]

17

Chinese

rs1059293

6 (IFNGR2)

0.27

1.1 × 10−2

[17]

18

Chinese

rs467960

21 (MX1)

0.68

2.2 × 10−2

[17]

19

Chinese

rs12614

6 (CFB)

1.89

1.28 × 10−34

[18]

20

Chinese

rs422951

6(NOTCH4)

1.27

5.33 × 10−16

[18]

21

Chinese

rs378352

6 (HLA-DOA)

1.26

1.04 × 10−23

[18]

22

Chinese

rs2853953

6 (HLA-C)

1.47

5.06 × 10−20

[18]

23

Chinese

rs1883832

20 (CD40)

1.21

2.95 × 10−15

[18]

24

Indonesian

rs9267665

6 (HLA)

2.05

1.0 × 10−17

[19]

25

Chinese

rs477515

6 (TRNAI25)

2.05

3.0 × 10−19

[20]

26

Indonesian

Chinese

rs3135363

6 (HLA-DR)

1.53,1.51

7.0 × 10−22

8.0 × 10−7

[19, 20]