Skip to main content

Table 1 GWAS on the genetic mechanism of chronic hepatitis B

From: Advances in the genome-wide association study of chronic hepatitis B susceptibility in Asian population

  Ethnicity SNP Chromosome (locus) Odds ratio P value (combined stage) References
1 Japanese
Korean
Indonesian
rs9277535 6 (HLA-DPB1) 1.39–1.89 3.0 × 10−54
−3.0 × 10−12
[10,11,12]
[18, 19]
2 Japanese
East Asian
Korean
rs3077 6 (HLA-DPA1) 1.78–1.89 2.0 × 10−61
−2.0 × 10−38
[10,11,12]
[14, 17, 18]
3 Japanese
Korean
rs2856718 6 (TRNAI25) 1.56–1.60 4.0 × 10−37
2.0 × 10−24
[11, 12]
[17, 18]
4 Japanese
Korean
Chinese
rs7453920 6 (HLA-DQB2) 1.81–2.00 5.0 × 10−37
~7.0 × 10−26
[11, 12, 16]
[17, 18]
5 Korean rs1419881 6 (TCF19) 1.37 1.0 × 10−18 [12, 18]
6 Korean rs652888 6 (EHMT2) 1.38 7.0 × 10−13 [12, 18]
7 Korean rs9394021 6 (VARS2) 0.78 1.7 × 10−6 [13]
8 Korean rs2517459 6 (VARS2-SFTA2) 0.56 1.7 × 10−10 [13]
9 East Asian rs9277542 6 (HLA-DPB1) 1.64 2.0 × 10−21 [14]
10 Chinese rs11866328 16 (GRIN2A) 1.68 2.0 × 10−8 [15]
11 Chinese rs4821116 22 (UBE2L3) 1.22 2.0 × 10−12 [16]
12 Chinese rs3130542 6 (TRNAI25) 1.33 9.0 × 10−14 [16, 18]
13 Chinese rs352140 3 (TLR9) 0.70 8.8 × 10−3 [17]
14 Chinese rs16944 2 (IL1B) 0.67 1.6 × 10−2 [17]
15 Chinese rs3212227 5 (IL12B) 1.38 2.1 × 10−2 [17]
16 Chinese rs3799488 13 (IFNGR1) 1.48 4.8 × 10−3 [17]
17 Chinese rs1059293 6 (IFNGR2) 0.27 1.1 × 10−2 [17]
18 Chinese rs467960 21 (MX1) 0.68 2.2 × 10−2 [17]
19 Chinese rs12614 6 (CFB) 1.89 1.28 × 10−34 [18]
20 Chinese rs422951 6(NOTCH4) 1.27 5.33 × 10−16 [18]
21 Chinese rs378352 6 (HLA-DOA) 1.26 1.04 × 10−23 [18]
22 Chinese rs2853953 6 (HLA-C) 1.47 5.06 × 10−20 [18]
23 Chinese rs1883832 20 (CD40) 1.21 2.95 × 10−15 [18]
24 Indonesian rs9267665 6 (HLA) 2.05 1.0 × 10−17 [19]
25 Chinese rs477515 6 (TRNAI25) 2.05 3.0 × 10−19 [20]
26 Indonesian
Chinese
rs3135363 6 (HLA-DR) 1.53,1.51 7.0 × 10−22
8.0 × 10−7
[19, 20]