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Table 2 Chemokines enhance wound repair in vitro

From: Chemokine ligand–receptor interactions critically regulate cutaneous wound healing

ng/ml Endothelial cells Fibroblasts Keratinocytes
10 100 500 1000 10 100 500 1000 10 100 500 1000
CCL1/I-309 40% 40% 60% n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d. n.d.
CCL3/MIP-1α × × × × × × × ×
CCL11/eotaxin 50% 100% 80% 30% 30% 50% 40% 40% 70% 60%
CCL17/TARC n.d. 50% 60% 50% 70% 40% 30%
CCL20/MIP-3α n.d. × × × × 100% 80% 60% 30%
CCL27/CTACK 40% 100% 80% 100% 70% 50% 80% n.d.
CXCL8/IL-8 40% n.d. × × × × 50% 80% 70% 80%
CXCL10/IP-10 n.d. × × × × 20% 80% 100%
  1. Wound repair of single path wounds in confluent cultures of human primary dermal microvascular endothelial cells, dermal fibroblasts and epidermal keratinocytes in the presence of indicated chemokines was monitored 12–18 h after injury. Percentage of wound closure was normalized to medium alone. Experiments were performed in triplicates and representative results of three different donors are shown. (−, closure of wound under 10%; n.d., not determined; ×, no receptor expressed for this ligand)